A lot of what he says is scientifically sound, but I think his attempt at creating (what looks to me to be) a unified theory of disease that centers around leptin/epigenetics/leaky gut (brb epileakyleptingenetics.com) has yet to be proven. I agree more with Paul Jaminet that malnutrition is the root cause of nearly all disease, though I suppose you could argue that leptin/epigenetic/leaky gut issues only occur in a state of malnutrition.

The problem that most have with him is that he is intentionally vague, which is probably necessary if you're a practicing doctor giving health advice over the internet. You'll never squeeze a dosage of something like K2 out of him because he's not your doctor and can't act as one. I guess those of us who are totally unqualified and un-credentialed have an advantage. Ahem. I suspect that the specific advice that he lays out for his actual patients is quite effective in improving their health and addressing whatever maladies they may have. I wouldn't be surprised if he didn't mention leptin to most of them. I don't think I've ever seen him give advice that would necessarily harm someone, so I think all told he's a net benefit to the community, especially when he talks about the things he does in his day job. If you have a slipped disc, you want to talk to him, not any of the rest of the people out there.

I've definitely gone in certain directions after reading something he's written that have improved my understanding of various things.

Let's not forget that this here internet is 99.9999999999% noise with the faintest coherent signal of what we might call truth trying to be heard. I've seen outright troll/spam posts that have introduced some new idea or sent me in a useful (non-Viagra) direction. I've talked to what must have been clinically insane homeless people in real life who have said profound things (amidst plenty of gibberish). Nearly everyone you meet has something to offer you in one way or another. I used to write people off as soon as they appeared to be unreliable in one way or another, but I've since become far more tolerant of the noise because when you wait it out, an interesting signal usually comes.

I think he supports the fundamental tenets of Paleo that MANY people would agree with

• Avoiding gluten grains (many places on his blog)
• Avoiding excess fructose (many places on his blog)
• Avoiding excess omega 3 and importance of O3-O6 ratio - http://jackkruse.com/is-fish-oil-good-or-bad/
• The importance of gut health - http://jackkruse.com/could-it-be-the-gut/
• The importance of sleep - http://jackkruse.com/sleep-ya-big-dummy/
• Exercise vis-a-vis hormesis - http://jackkruse.com/category/hormesis/

EDIT - My open disagreements notwithstanding, I have never said Quilt was completely wrong. Far from it and I am not alone here. People reacting negatively to the other thread seem to think that it is black or white. I prefer my 60" HD color TV in the 21st century.

Here is what I suggest. Find one thing that Dr K has said with which you disagree. Make sure that your disagreement isn't trivial - i.e., that the outcome has important health implications. Find the place where he talks about it on his blog, which you can do by Googling 'Jackkruse' plus the main word that you are interested in. I recently did this to quickly find his comments on carnosine, for example. Formulate your disagreement as a question. Post it as a comment (on his blog). He will respond.

Kruse is cool like that. Dislike his style all you want, but he seems to take pleasure in defending himself. I'm pretty sure that he doesn't say anything without having a reason for it. This has some downsides. However, it also has a major upside: if ask him about it, he'll respond, and often in a spirited fashion.

There is no need to complain about Kruse. It's probably not the most productive option. I suggest talking to him about it. For a busy doctor, Kruse is surprisingly available.

In the most general sense, my perception is that Dr. K is saying a messed up "broken" metabolism can impede weight loss and in his best judgment leptin may be the most important factor to consider in effecting recovery to your metabolism. He's also sharing a remedy that seems to work for many people.

He speaks with a loud voice to me because he has seen ravaged metabolisms up close both directly and indirectly because he's simply in the right place to make relevant observations.

In my opinion he is right about many things. However...he is wrong about things also. And I find it is in his inability to admit he's wrong or admit that he might not know everything about everything.

He makes claims on here that need to be substantiated - he is not making n=1 statements; he is making blanket statements based on 'hundreds and thousands of patients'. He MUST hold himself accountable for these claims. The burden of proof is on him with such huge statements!

As many have stated it is in his delivery where he needs a little work. His dismissive tone to some is quite condescending - and I have a problem with that. I don't think that anyone likes being dismissed as uninformed or downright stupid.

I truly beleive that his heart is in the right place. And I think that ph is a more interesting place with him.

Oh and here's my mothering for the day: ((I think we're in need of a serious group hug here on ph!))

He's pretty right about leptin and it's importance. I've not found anything to contradict anything he says, here's a partial list....

Leptin:

• Directly affects TRH (Guo and others 2004)

• Stimulates the sympathetic nervous system (Ren 2004)

• Works on the same receptors as insulin; insulin is an endogenous leptin antagonist (Lustig AHS)(Walder and others 1997; Ceddia and others 1998)(Kieffer and others 1997; Lam and others 2004)

• Leptin reduces GLUT2 glucose transport (Lam et al. 2004)

• Obesity is related to an impaired regulation of leptin by insulin, since leptin levels increased in lean men but decreased in obese men following a high-fat meal. (Imbeault and others 2001)

• Decreases hepatic cholesterol synthesis, promotes hepatic uptake of plasma cholesterol (VanPatten and others 2001)

• Testosterone lowers leptin (Ogura and others 2000; Soderberg and others 2001; Casabiell and others 2001)

• Leptin inhibits cortisol and corticosterone secretion (Szucs and others 2001)

• Growth hormone lowers leptin (Isozaki 1999)

• Fructose decreases leptin (Teff and others 2004)

• Leptin activates fatty acid oxidation and decreases TG content in the heart (Atkinson and others 2002)

• Plasma leptin levels are controlled by production rate rather than clearance rate. (Schoeller and others 1997)

• Leptin reduces the rate of glucagon-stimulated glycogenolysis. (Ceddia and others 1999)

• ROS are involved in leptin signaling; chronic oxidative stress in endothelial cells under hyperleptinemia may promote atherosclerosis (Bouloumie and others 1999)

• Leptin regulates endocrine and immune functions, playing a role in innate and acquired immunity. (Faggioni and others 2001)

• Leptin may be a sweet-sensing suppressor (Kawai and others 2000; Shigemura and others 2004)

• Vitamin D inhibits leptin (Menendez and others 2001)

• Inflammation increases leptin (Gualillo and others 2000)

• Diurnal leptin rhythms are entrained to meal patterns (Schoeller et al. 1997)

• Ghrelin levels are affected by meal timing (Kim and others 2004)

Leptin Resistance:

• Leptin increases FA oxidation in skeletal muscle of lean, but not obese humans, thus demonstrating the development of peripheral leptin resistance in obese human skeletal muscle. (Steinberg and others 2002; Van Heek and others 1997)

• In obesity leptin receptors and subsequent signaling events are down-regulated and basal insulin signaling is impaired (Brabant and others 2005)

• Hyperleptinemia correlates with hyperphagia, insulin resistance and other markers of the metabolic syndrome including obesity, hyperlipidemia and hypertension, independent of total adiposity. Elevated plasma leptin levels may be an independent risk factor for the development of cardiovascular disease. (Ren 2004)

• Chronic fructose consumption induces leptin resistance prior to body weight, adiposity, serum leptin, insulin, or glucose increases, and this fructose-induced leptin resistance accelerates high- fat induced obesity.(Shapiro and others 2008)

• Triglycerides are an important cause of leptin resistance as mediated by impaired transport across the BBB. Decreasing trigs may potentiate the anorectic effect of leptin by enhancing leptin transport across the BBB. (Banks and others 2004)

• NPY neurons are a major target for leptin action and partly explain the hyperphagia seen when leptin signalling is defective, and the accompanying decrease in energy expenditure (Wilding 2002)

• In most overweight individuals, physiological regulation of body weight by leptin seems to be disturbed, representing “leptin resistance.” This leptin resistance at the level of the pancreatic B-cell may contribute to dysregulation of the adipo-insular axis and promote the development of hyperinsulinemia and manifest type 2 diabetes in overweight patients. (Seufert 2004)

Brain

• Leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin’s anorectic effect. Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake.(Cota and others 2006)

• Ghrelin appears to block leptin action (Wilding 2002)

• Leptin can rescue normal pulsatile GH secretion by preventing the inhibitory action of NPY on GH secretion. (Vuagnat and others 1998)

• NPY/AgRP neurons are inhibited by leptin, insulin and PYY, whereas they are stimulated by ghrelin (Morton and others 2006)

• Obese have more AgRP than non-obese (Katsuki and others 2001)

• Agouti inhibits the anorexic effects of leptin, up-regulates adipocyte leptin expression, and regulates adipocyte lipid metabolism, functioning both to increase the expression and activity of lipogenic genes and to inhibit lipolysis. (Zemel 1998)

• Agouti increases leptin synthesis and secretion.(Claycombe and others 2000)

• Insulin resistance upregulates cholesterol synthesis (Gylling and others 2010)

Energy Regulation

• UCP3 is a mediator of thermogenesis; prevents excess fatty acids from accumulating in the mitochondrial matrix regulated by thyroid and leptin (Gong and others 1997)

Atkinson LL, Fischer MA & Lopaschuk GD. 2002. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J Biol Chem 277(33):29424-29430.

Banks WA, Coon AB, Robinson SM, Moinuddin A, Shultz JM, Nakaoke R & Morley JE. 2004. Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes 53(5):1253-1260.

Bouloumie A, Marumo T, Lafontan M & Busse R. 1999. Leptin induces oxidative stress in human endothelial cells. Faseb J 13(10):1231-1238.

Brabant G, Muller G, Horn R, Anderwald C, Roden M & Nave H. 2005. Hepatic leptin signaling in obesity. Faseb J 19(8):1048-1050.

Casabiell X, Pineiro V, Vega F, De La Cruz LF, Dieguez C & Casanueva FF. 2001. Leptin, reproduction and sex steroids. Pituitary 4(1-2):93-99.

Ceddia RB, Lopes G, Souza HM, Borba-Murad GR, William WN, Jr., Bazotte RB & Curi R. 1999. Acute effects of leptin on glucose metabolism of in situ rat perfused livers and isolated hepatocytes. Int J Obes Relat Metab Disord 23(11):1207-1212.

Ceddia RB, William WN, Jr., Lima FB & Curi R. 1998. Leptin inhibits insulin-stimulated incorporation of glucose into lipids and stimulates glucose decarboxylation in isolated rat adipocytes. J Endocrinol 158(3):R7-9.

Claycombe KJ, Xue BZ, Mynatt RL, Zemel MB & Moustaid-Moussa N. 2000. Regulation of leptin by agouti. Physiol Genomics 2(3):101-105.

Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC & Seeley RJ. 2006. Hypothalamic mTOR signaling regulates food intake. Science 312(5775):927-930.

Faggioni R, Feingold KR & Grunfeld C. 2001. Leptin regulation of the immune response and the immunodeficiency of malnutrition. Faseb J 15(14):2565-2571.

Gong DW, He Y, Karas M & Reitman M. 1997. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem 272(39):24129-24132.

Gualillo O, Eiras S, Lago F, Dieguez C & Casanueva FF. 2000. Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci 67(20):2433-2441.

Guo F, Bakal K, Minokoshi Y & Hollenberg AN. 2004. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology 145(5):2221-2227.

Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M & Miettinen TA. 2010. Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study. J Lipid Res 51(8):2422-2427.

Imbeault P, Doucet E, Mauriege P, St-Pierre S, Couillard C, Almeras N, Despres JP & Tremblay A. 2001. Difference in leptin response to a high-fat meal between lean and obese men. Clin Sci (Lond) 101(4):359-365.

Isozaki O, Tsushima, T., Miyakawa, M., Demura, H., Seki, H. 1999. Interaction between leptin and growth hormone (GH)/IGF-I axis. Endocr J. 46(Suppl):S17-24.

Katsuki A, Sumida Y, Gabazza EC, Murashima S, Tanaka T, Furuta M, Araki-Sasaki R, Hori Y, Nakatani K, Yano Y & Adachi Y. 2001. Plasma levels of agouti-related protein are increased in obese men. J Clin Endocrinol Metab 86(5):1921-1924.

Kawai K, Sugimoto K, Nakashima K, Miura H & Ninomiya Y. 2000. Leptin as a modulator of sweet taste sensitivities in mice. Proceedings of the National Academy of Sciences 97(20):11044-11049. Kieffer TJ, Heller RS, Leech CA, Holz GG & Habener JF. 1997. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 46(6):1087-1093.

Kim HH, Lee S, Jeon TY, Son HC, Kim YJ & Sim MS. 2004. Post-prandial plasma ghrelin levels in people with different breakfast hours. European Journal of Clinical Nutrition 58(4):692-695.

Lam NT, Cheung AT, Riedel MJ, Light PE, Cheeseman CI & Kieffer TJ. 2004. Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells. J Mol Endocrinol 32(2):415-424.

Menendez C, Lage M, Peino R, Baldelli R, Concheiro P, Dieguez C & Casanueva FF. 2001. Retinoic acid and vitamin D(3) powerfully inhibit in vitro leptin secretion by human adipose tissue. J Endocrinol 170(2):425-431.

Morton GJ, Cummings DE, Baskin DG, Barsh GS & Schwartz MW. 2006. Central nervous system control of food intake and body weight. Nature 443(7109):289-295.

Ogura T, Tobe K, Mimura Y, Otsuka F, Yamauchi T, Imai A, Tsukamoto C, Iwasaki Y & Matsuura K. 2000. Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism. J Endocrinol Invest 23(4):246-250.

Ren J. 2004. Leptin and hyperleptinemia - from friend to foe for cardiovascular function. J Endocrinol 181(1):1-10.

Schoeller DA, Cella LK, Sinha MK & Caro JF. 1997. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest 100(7):1882-1887.

Seufert J. 2004. Leptin effects on pancreatic beta-cell gene expression and function. Diabetes 53 Suppl 1:S152-158.

Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ & Scarpace PJ. 2008. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol 295(5):R1370-1375.

Shigemura N, Ohta R, Kusakabe Y, Miura H, Hino A, Koyano K, Nakashima K & Ninomiya Y. 2004. Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology 145(2):839-847.

Soderberg S, Olsson T, Eliasson M, Johnson O, Brismar K, Carlstrom K & Ahren B. 2001. A strong association between biologically active testosterone and leptin in non-obese men and women is lost with increasing (central) adiposity. Int J Obes Relat Metab Disord 25(1):98-105.

Steinberg GR, Parolin ML, Heigenhauser GJ & Dyck DJ. 2002. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 283(1):E187-192.

Szucs N, Varga I, Jakab C, Patocs A, Glaz E, Toth M, Kiss R & Racz K. 2001. Leptin inhibits cortisol and corticosterone secretion in pathologic human adrenocortical cells. Pituitary 4(1-2):71-77.

Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D & Havel PJ. 2004. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 89(6):2963-2972.

Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD & Davis HR, Jr. 1997. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 99(3):385-390.

VanPatten S, Ranginani N, Shefer S, Nguyen LB, Rossetti L & Cohen DE. 2001. Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance. Am J Physiol Gastrointest Liver Physiol 281(2):G393-404.

Vuagnat BA, Pierroz DD, Lalaoui M, Englaro P, Pralong FP, Blum WF & Aubert ML. 1998. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat. Neuroendocrinology 67(5):291-300.

Walder K, Filippis A, Clark S, Zimmet P & Collier GR. 1997. Leptin inhibits insulin binding in isolated rat adipocytes. J Endocrinol 155(3):R5-7.

Wilding JP. 2002. Neuropeptides and appetite control. Diabet Med 19(8):619-627. Zemel MB. 1998. Agouti/melanocortin interactions with leptin pathways in obesity. Nutrition Reviews 56(9):271-274.

@ Quilt above

Funny? Not really given our nipple phobic society. Women are the worst. Check out all the fashion "experts" gals listen to who say you must wear a bra. Tatas must be uplifted for a more "flattering look." How come these same experts don't push bras on all the estogenifed men waddling with breasts...or maybe single cup bras for beer bellies. No, this wouldn't happen because men would tell them to f off. But women -- oh, we bitch and moan about oppression yet line up like mindless sheep to purchase whatever Madison Avenue says will "fix" us. All one has to do is look at the suit of armor type bras people wear nowadays to see we are sexually conflicted. On the one hand "hook-ups" (aka one night stands) are de rigour -- but yet women wear suit of armour padded or these weird hard cup bras to conceal their nipple erections. We are inundated with in your face porn and yet people are scared of freaking female nipples. I know men who love strip joints but get all purile if confronted with a woman breastfeeding in public. But seriously, women are the worst. They are the first to say -- "you need a bra" or "put on a bra" - - that's how conditioned they are to be ashamed of their own sex's anatomy. First corsets, now suit of armour bras. Some things never change...oh, except now padded bras are now being marketed to 5 year olds...Don't get me started on what constant contact with toxic chemical fake material bras worn all day and some even wear them all night too could do to health of breast tissue over time. If someone wants to wear a bra -- some big boobed gals get back/shoulder issues without a bra -- fine -- but it should be a personal choice -- not dictated by our nipple phobic society. Rant over. Need an oxytocin hit to calm down now...

Quilt on turmeric:

"Turmeric should be in the water supply in my view."

Plus one...

In a discussion about the medical field, Dr. Kruse suggested I not be passive when it comes to my health care, be aggressive, and ask for what it is I really want. He was right about that.

I think he's right about a whole lot more than he's wrong about. As mentioned above, you have to actually do your own research on the statements he makes but that's not a bad thing.

For example, what he wrote about uncoupling proteins and fat burning really interested me. There are TONS of articles on it, if I really wanna understand it I need to do my homework.

http://www.jbc.org/content/272/39/24129.full

http://journals.cambridge.org/download.php?file=%2FPNS%2FPNS63_02%2FS0029665104000382a.pdf&code=52f4669b01a60ed0417e3dfa463249ff

http://www.jssm.org/vol4/n2/10/v4n2-10pdf.pdf

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001397

In my opinion, the two things that Dr.K is mostly right about and should be emphasized are these:

1 Even strict Paleos need extensive lab testing

Paleo is great and is by far the best approach to diet and life, however, what people should realize is that MOST of us are seriously damaged and Paleo will not be enough. Our parents made poor dietary choices, their parents did do, and etc. We did for a big portion of our lives as well. We cannot expect that by simply being strict Paleo, all these years of damage can be reversed for all of us. It might work for some lucky Paleos, however, most of us have specific health or genetic issues that need to be identified and addressed by supplementation. The only reliable way to identify and improve these issues is through extensive lab testing and a knowledgeable doctor. There is no universal diet that will cure everyone and the Paleo approach needs to be tweaked for the people that have less stellar results.

http://jackkruse.com/what-are-the-optimizing-labs/

2 The medical profession needs to change

This idea of his is very significant. Treating symptoms and ignoring diet and lifestyle choices is killing people. This needs to be addressed. Doctors need to be more knowledgeable about nutrition and how it is reflected in the lab results of their patients.

http://jackkruse.com/changing-your-doctor-changing-your-life-changing-your-weight-changing-your-mind/

http://jackkruse.com/we-need-your-input-for-2012-ahs-conference/

This is an almost impossible question to answer. Why? Because Jack, himself, says very little directly about leptin. What you're asking people to do, essentially, is research for Jack if following his protocol actually improves leptin resistance, as quantified by more than just nebulous criteria like craving sweets from 1:15-2:39pm on alternate Sundays of odd numbered months.

Has Jack ever published his litany of test results and gone all Ned Kock on them to show where he comes up with the epigenetic switch he's flipped or needs to or whatever?

He's right about nipple stimulation and oxytocin's beneficial effects on the breast as well as entire body. Google it. Massage in general benefits the body and aids healing. Breast massage is prescribed in Asian medicine -- qigong massage comes to mind -- to alleviate breast cysts, lumps, pain. Massage is important therapy (not "woo") in Japan, Thailand, Korea, China etc. There is an association between breast-feeding and lower breast cancer risk which it's postulated is due to nipple stimulation. When those who have breast fed do get cancer, it's sometimes correlated with the breast not used predominantly for the breast feeding. Google it. Massage moves lymph fluid and reduces swelling. Don't knock it until you've tried it. Many perimenopausal, menopausal and post-menopausal complain that their sex drive is in the toilet. No orgasms, not oxytocin. Clitoral orgasm releases oxytocin and also help keep cervixs clear so tell your cavemen or cavepartners whatever the case may be to get busy or if you're flying solo -- at least masturbate. Lots of chicks are squeamish about masturbation. Get over it gals.

The disagreements I'm seeing with Dr. Kruse so far don't appear to have any substance or specificity to them. I don't think he's vague at all, his explanations and recommended treatments of the many kinds of diseases are very specific. He may answer questions sometimes by saying he can't give you a specific answer to your question without seeing all lab results for you, which is what I'd say if I was a doctor with my own blog many times because you can't be everyone's personal doctor simply by them asking a question. What you can do is give them as much info as possible to lead them in the right direction. Doctors should be all about empowering patients through self-knowledge. Making too many specific recommendations for people you don't know about their health problems isn't doing that, rather it's closer to doing what doctors in the conventional system do, which is creating a state of dependency on the doctor and looking to him for all of your answers. As Hippocrates said, "Let food be thy medicine and medicine be thy food." This means take responsibility for your health by changing your diet until you find the diet that allows you to be the healthiest. Then, if you still have some problems, ask a doctor for feedback. Disagreement within the scientific and medical community is healthy and necessary, so if we have things that we don't agree with Dr. Kruse about, state them clearly so we can discuss them and attempt to arrive at the truth on the subject. There's always room for debate about science, but so far I don't see that happening regarding Dr. Kruse's arguments on every topic. No one person including Dr. Kruse has all the answers, last time I checked there's only one God, but the more open minded we are and willing to admit when our idea or opinion is wrong, the more chances we have of finding the truth. Dr. Kruse's main argument as I understand it is that leptin is one of the master energy controls in the body, and is needed for the mitochondria to convert food to energy in the form of heat. When we have a standard American diet high in sugar and other neolithic agents of disease from various sources, we develop leptin resistance, which impacts all other systems of the body. Focusing on the gut, as Dr. Kruse also does, is also crucial because without absorbing nutrients from our food and protecting the inside of our body from the outside world, everything else begins to fall apart. I see nothing wrong with this approach to medicine. I'll sum up my comments with this quote: "Criticism is necessary and useful; it is often indispensable; but it can never take the place of action, or be even a poor substitute for it. The function of the mere critic is of very subordinate usefulness. It is the doer of deeds who actually counts in the battle for life, and not the man who looks on and says how the fight ought to be fought, without himself sharing the stress and the danger." -Theodore Roosevelt Also, read his famous "man in the arena quote", I think it's very relevant here.

Let me repeat. This guy is an MD.How many MD's have the balls to throw a finger at their own Mafia-like organization? If he's wrong 50% of the time, he's 47% more correct than the rest of his medical brethren. He is risking a lot. The AMA will try to get him. Think about it. No one will have his back in a malpractice suit. He'll have to become a personal trainer , or nutritional consultant like myself. :) ( Google: Sarah Myhill MD U.K) They took her license away for a while. (Google: Tony Soprano )

Dr. K is a big proponent of bioidentical hormones for postmenopausal women with signs of osteopenia or osteoporosis. The question I have is whether the osteopenia/osteoporosis can be prevented by switching to a paleo diet.

Bone Density/Osteoporosis

Christiansen, C, Riis BJ, Nilas L, Rodbro P, "Uncoupling of bone formation and resorption by combined oestrogen and progestagen therapy in postmenopausal osteoporosis," Lancet 12 October 1985:800-801.

Cummings SR, Mevitt MC, Browner WS et al for the Study of Osteoporotic Fractures Research Group, "Risk Factors for Hip Fracture in White Women," N Engl J Med 1995;332:767-73.

Dargent-Molina P, Favier F, Grandjean H, Baudoin C, Schott AM, Hausherr E, Meunier PJ, Br art G, for the EPIDOS Group, "Fall-related factors and risk of hip fracture: the EPIDOS prospective study," Lancet 1996; 348: 145-49.

Dempster DW, Lindsay R, "Pathogenesis of osteoporosis," Lancet 1993; 341:797-801.

Hoskins D, Chilvers CED, et al, "Prevention of bone loss with alendronate iin postmenopausal women under 60 years of age," NEJM 1998; 338:485-492.

Ojasoo T, "Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data," J Steroid Biochem Molec Biol 1994; 48:31-46.

Prior JC, "Progesterone as a Bone-Trophic Hormone," Endocrine Reviews 1990; 11:386-398.

Tamoxifen Studies

The Lancet 11 July 1998; 352: 80-81, 93-97, 98-101, Editorial by Kathleen I. Pritchard, U. of Toronto, Ontario.

Powles T, Eeles R, Ashley S, Easton D, et al, "Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomized chemoprevention trial," Lancet 1998; 352: 98-101.

Veronesi U, Maisonneuve P, Costa A, Sacchini V, et al, "Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomized trial among hysterectomized women," Lancet 1998;352:93-97.

Estrogen Supplementation

Cummings SR, et al, "Endogenous hormones and the risk of hip and vertebral fractures among older women," NEJM, 10 Sept 1998; 339: 733-738.

Hulley S, et al, "Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women," JAMA, 19 August 1998; 280: 605-613.

Prior JC, "Perimenopause: the complex endocrinology of the menopausal transition," Endocrine Reviews 1998; 19(4):397-426.

Over on Mark's Daily Apple, Dr. Kruse started posting a year or so ago, adding to other threads and answering people. Then he started talking about "The Quilt" and then someone started a thread http://www.marksdailyapple.com/forum/thread32345.html that has over 10,000 replies and 439,000 views since June 15, 2011. We refer to it as the 'Monster Thread'.

He now posts soley on the Monster Thread every day or two. Sometimes he completely ignores requests for info, sometimes he just throws stuff out there unsolicted. I know I just cruise through the pages looking for his replies as so many others are personal-journal type stuff from people doing the reset.

My impression is that he gives good advice and really does his homework. I think he is right on about the supplements he recommends, the testing he recommends, and the diet he recommends. His advice was the first I heard advocating different macros based on time of year/daylight, and that seems to work for me, too.

The Quilt's ego will repel people who may need his ideas implemented in their lives. His arrogance keeps him from seeing the role he plays in this.

THE obvious he recommends is prolly a good idea but it has been said for decades

-eat high protein to lose weight & blunt appetite -cut crap carbs if your fat