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Jack Kruse: http://jackkruse.com/my-leptin-prescription/ (This is intended for 6-8 weeks or until leptin sensitive and a paleo diet post reset.)

Ron Rosedale's website: http://drrosedale.com/healthplan.htm (I included Rosedale's b/c his was shorter than Kruse's)

Rosedale:

"Here are some basic rules to follow which will keep you on a path to ultimate health and longevity:

FEEL GOOD ABOUT YOURSELF You are about to embark on a program that will produce wonderful results for your body. You will learn a new way of eating that will make you look better and feel better than you have in years. Within a short time--usually within two to three weeks–most of you will notice that you look leaner, your clothes fit better, and you have energy to spare. There will also be some amazing things happening to you that aren’t visible, yet are ever more important. Your Longevity Profile--that is your biomarkers of aging--will be vastly improved as you regain your leptin sensitivity, and along with losing excess fat you will be de-aging your body and reinventing your body. So smile, feel good about taking this positive step, and get started.

AVOID SUGAR AND STARCH To jump start the fat burning process, during the first 3 weeks on the meal plan, eat as little non fiber starch or sugar as possible. You don’t have to count carb grams; just don’t eat non fiber carbs. Avoid all starches such as potatoes, bread, rice, pasta, cereal, corn and ALL GRAINS (yes, even whole grains.) Fill up with your plate with vegetables, with the exception of those high in sugar including beets, yams, carrots or tomatoes (though a few sliced carrots or cherry tomatoes in salads is okay). Limit your fruit intake to a small amount (1/4 cup maximum daily) of berries, preferably blueberries. (Diabetics should avoid starch and sugar all the time.) After the first 3 weeks, you can add a bit more starch to your diet (such as a couple of slices of high fiber, low carb bread) as long as this does not increase your cravings for more.

EAT THE RIGHT AMOUNT OF PROTEIN FOR YOU Remember, this is a high fat diet, not a high protein diet. You should eat the right amount of protein for your body type.

DON’T BE AFRAID OF FAT--BUT EAT GOOD FAT This is a high fat diet, so if you are hungry, you may eat fat! But stick to the good fats found in nuts, avocados, fatty fish, olives, etc.

LIMIT SATURATED FAT FOR THE FIRST THREE WEEKS When you want to lose weight, what you really want to lose is saturated fat. So stop eating it, at least for the first three weeks you are on the meal plan. Pass on the beef, pork, lamb and most dairy products and eat primarily fish, nuts, chicken, vegetables and no fat cheese. After the first three weeks on the meal plan, you can eat foods that are higher in saturated fat (such as lean beef, lamb and pork) although those wishing to continue losing weight should not eat very much of these foods.

EAT WHEN YOU ARE HUNGRY I don’t want you to walk around hungry. When you are hungry, eat good fats, protein (if you have not exceeded your protein limit) and fiber (like vegetables.) Good snacks include raw or dry roasted nuts, nut butters, guacamole and vegetables and dip. (See recipes page xx.) You should not be hungry on this diet, I mean it! If you are hungry, have a handful of nuts or any of the healthy snacks listed in the menus. If you have trouble feeling full without eating a lot of starch, fill up on vegetables. Your cravings for sweets and starches, which are similar to an addiction, should subside within three weeks.

DRINK LOTS OF WATER Stick to water, seltzer, or flavored water (tea and herbal teas.) No soda of any type, even diet soda, and no juice.

DON’T EAT A LOT AT ONE TIME. When you are hungry eat a small meal or snack rather. It’s far better for your metabolism to eat several small meals or snacks throughout the day than three large meals.

EAT SLOWLY If you bolt down your food, your brain will not have the chance to know that you are no longer hungry, and you will keep eating. If you eat slowly, your brain will get the message that you are filling up, and you will know when it’s time to stop eating.

DON’T EAT FOR AT LEAST THREE HOURS BEFORE BEDTIME Your last meal in the evening should be at least twelve hours from your first meal of the morning. This will give your body the time it needs to rest and heal, and you will find that you are sleeping better. Digesting food is hard work. Let your digestive system sleep also. Drinking water, however, is okay.

EXERCISE AFTER THE LAST MEAL OF THE DAY (IF POSSIBLE) Do 15-20 minutes of mild resistance exercise (see chapter xx) or take a short walk (preferably uphill.) This will help burn up sugar, and prime you for a night time of fat burning. Then you should keep burning fat all night long, and the more fat you burn, the better you get at it. Even broccoli has some sugar and I want you to burn it off as soon as possible. What I don’t want you to do is to eat late, lie down on the sofa and go to sleep. This will force your body to be working hard trying to digest all that food just when it should be winding down for sleep.

And finally......

DON’T SLIP UP– AT LEAST FOR THE FIRST THREE WEEKS It takes about three weeks for your metabolism to retool so that you switch from being a “sugar burner” to a “fat burner.” Once your body and brain have made the switch, you will feel the difference. You will have more energy, better mental focus, and you’ll even be sleeping better! In my experience, I have found that after feeling the difference, and "retooling" the brain's needs and desires, few people want to go back to their old eating patterns. NOBODY’S PERFECT It is far better not to, but IF YOU DO SLIP UP...EXERCISE IT OFF. If you “forget” and eat a sandwich with two slices of bread, or eat a cookie, go for a brisk 20-30 minute walk or undertake other exercise immediately after eating. If you don’t burn off those starchy calories right away, they will raise your blood sugar, raise your leptin and insulin levels, prevent fat burning, and turn to fat, all of which get you right back to a deranged metabolism."

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Our difference are these....i love sat fat especially long chain he does not. I dont think protein stimulating mTor is bad when inflammation is low and i think carbs are fine if inflammation and cortisol is low and it is yoked to the light cycle. He believes leptin levels matter i dont. I think wht is happening at the leptin receptor is all that matters. I believe in neuroplastic repair of the leptin receptor and i dont think ron has ever commented upon this. Those are the differences i see. – The Quilt Nov 6 at 15:21
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I eat tons of SFA every day. I eat enough protein and fat in the predawn am to make it through to 5pm dinner without snacking ever. The only nut I eat are 3 Brazil nuts a week for selenium. No other as it messes with O6/O3 ratio. Weight stable at 12% BF. R sells books, K does not. They are both on the same road to optimal health for patients. No R haters here, only K haters..yet both are on the same road to optimal health. Both place leptin at the centerpiece of optimal health. They are not far apart. – Dextery Nov 6 at 17:56
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So many of these recommendations seem utterly arbitrary. – Travis Culp Nov 6 at 18:13
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Ron and I agree on most things.....where we dont agree is at the fringe of where science is right now. The CRON data in primates and humans will be out in 25-30 yrs so we will know soon who is right. The interesting thing about mTOR and IGF1 is that most articles dont talk about the surrounding cellular terroir. I think IGF1 and mTOR are bad news in people with elevated HS CRPs like T2D etc.....but I don't buy the argument that those two pathways mean bad news if the person has no baseline inflammation. I think Art DeVany and Jeff Life are two great examples of that. So was J LaLanne! – The Quilt Nov 6 at 22:04
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Quilt, terroir is not a word. What do you mean by cellular terroir? – Namby Pamby Nov 7 at 1:44
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13 Answers

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Melissa, I love you and your blog, I am a fan...but Rosedale is not saying fish and chicken are healthier than beef or lamb. He is saying in the first 3 weeks, to become a more efficient ketone burner, limit SAT fat till you are on the beam. Then, if you have no elevated ferritin, eat lamb, beef.I have eaten with him many times as he lathered bearnaise sauce over a steak, only round 5 oz. though. Read Rosedale's work and this is all there.

On a personal note, I don't get the trashing of giants, like Rosedale,who, for over 30 years have been healing, helping, promoting aging research, fighting big pharma, pissing off most every commercial conglomerate and ignorant doctors not interested in expanding their understanding of ageing. He is the mentor to the Drs. Eades, mentor to Dr. Eric Westman, debated Dr. Dean Ornish on PBS and trashed him so bad that Ornish threatened to sue PBS if they aired the program...I have seen it.

Dr. Rosedale is not here to promote CW, far from it. He was talking insulin 25 years ago, leptin since it was discovered. While most of us here on PH were still in grammar school, he was fighting this war. Not when it is becoming popular now...but long ago when there are no support systems or comrades in arms.

He became so frustrated with the US systems and medical establishments that he retreated to India, where for the last 4 years, he has been conducting free retreats, where he has personally lost a fortune, training obese and diabetics here how to regain health. This movement sprung up only since he has been gone. He would rather be in India where people are more open to this than in the US where he has had to fight alone.

Seeing that the landscape is changing in the US, he is willing to get back in the battle. He is the ally of all here. He is a brilliant man and the debates are not over on the better ways to approach health, far from it.

So please, everyone, support getting all the players together at the next AHS meeting to roundtable and debate there, meet and discuss and not just "present". We have a seat on a movement that can change the course of health here. Lets fight together, with a sense of humor...and read each other's blogs, like Hunt Gather Love and Dr. Rosedale's.

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Andre, so beautifully said.Rosedale has fought and continues for the greater good. In 1999 when his talk was transcribed and posted on the web 'insulin and it's metabolic effects' you can search it today, it's listed on endless medical and science sites and till today is still ground breaking. Mercola himself credits Rosedale for all he knows on the subject and mercola's post of this talk is almost reaching over 200,000 hits. Eric Westman, told Rosedale he was way ahead of his time and that was a decade ago. Rosedale continues to be way ahead, though most do see it until several years after. – Fiona Nov 7 at 8:25
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Rosedale is great hacker. Respect ! Haters are always there. – majkinetor Nov 7 at 9:54
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Melissa, you may still need to get a few more decades under you before it starts to make sense. Right now, you're bulletproof. – edrice Nov 7 at 15:15
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I'm not bulletproof. I had asthma, gerd, arthritis...I was overweight. I did quite well on keto at first, but later developed other issues. – Melissa- huntgatherlove.com Nov 7 at 17:39
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and according to Rosedale, I have diabeetus. How's that for bulletproof? – Melissa- huntgatherlove.com Nov 7 at 17:42
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Dear Dr. Rosedale,

My "hilarious" comment was an immediate thought I posted on facebook and I certainly didn't mean it as an actual response to your comments, which would require being much more thoughtful. In that sense I apologize that it made it's way back to you.

I agree that I have "some degree of leptin and insulin resistance," and thank God I do because the alternative to having "some degree" of resistance to any hormone would be infinite sensitivity. This is of course impossible to have, but insofar as one could asymptotically approach infinite sensitivity to a hormone it would probably spell complete disaster for the body as it would make it more difficult to regulate the response to these hormones.

This is somewhat analogous to saying, "Chris, like everyone else, drives slowly to work to some degree." If I drove too quickly, I'd get in a car accident, and although I'm not an expert in physics my understanding is that if I drove at a speed approaching infinitity I would spontaneously combust. Clearly if I took a day to get to work every day, I'd never get anything done, but you can't fault me for driving (or biking, or walking) at a reasonable pace consistent with traffic norms.

I don't speak out of total ignorance about hyperglycemia and AGE formation. I'm quite familiar with the concept of non-enzymatic glycation as my life is mostly consumed with reading the literature and performing original research on this topic right now. You might find this blog post of mine interesting:

Where Do Most AGEs Come From? O Glycation, How Thy Name Hast Deceived Me!

http://blog.cholesterol-and-health.com/2011/10/where-do-most-ages-come-from-o.html

Most AGEs come from dicarbonyls, not directly from glucose. As such, targeting even normoglycemic levels of blood glucose as the primary culprit in their formation strikes me as unlikely to be very productive. I have never seen any evidence that diabetes is a "linear, no-threshold" expression of intrinsically toxic blood glucose, and it is not because I haven't searched the scientific literature for evidence that normoglycemic fluctuations in blood glucose are harmful. I have.

I don't have time to debate this extensively here, but I did want to offer a brief apology for carelessly laughing off your statement, and to clarify why I nevertheless disagree with it.

Chris

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I don't care how reactive carbonyls are...this extended analogy is still out of control. – Kamal at PainDatabase.com Nov 8 at 2:09
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Taking it another direction: I love my body and I want it to last a long time. Should I be apologizing to my body for increasing its blood glucose 0.01%? Or does love mean never having to say you're sorry? – Kamal at PainDatabase.com Nov 8 at 3:25
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You're afraid of raising leptin because you might impair leptin sensitivity. It is better to leptin and lose than to have never leptin'd at all. – conciliator Nov 8 at 6:12
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I'm pretty skeptical about less glucose metabolized from diet leading to more insulin sensitivity. The people eating more carbs tend to have better insulin sensitivity than people eating low carb based upon various studies that Jaminet and Carbsane have reviewed. Even Peter at Hyperlipid seems to say that it is common knowledge that low-carbers will have higher fasting glucose than carb eaters. – Paleo2.0 Nov 8 at 14:15
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Let me just state that there are far too few ridiculous analogies in the paleosphere. Everyone should post at least one per day. In fact, it's a bit like...[CENSORED BY KAMAL] – Travis Culp Nov 8 at 17:12
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I apologize for having to give only a short clarification and reply at the moment.. I am currently on a flight with just my iPad... As far as saturated fat..it has been quite clearly shown that the ease of burning saturated fats is directly correlated with chain length. I don't have citations with me but I believe that I had posted some for a prior question or comment on this site. (Long chain)saturated fats have also long been shown to impair insulin sensitivity.. See articles by Storlein. However, these studies like most all nutrition studies are done on high carb adapted individuals. It has been shown by me and others that it takes several weeks to adapt well to a very low (non fiber) carb, higher fat diet, especially when protein is also kept in moderation, therefore reducing alternate gluconeogenic substrates. This is why I recommend reduced long chain sat fats for the first few weeks. It seems to make the all important transition easier MCTs are great always.

My diet arose almost 2 decades ago to best treat diabetics and CV patients as models for accelerated aging. it also became very clear to me then that we all have nearly the same metebolic problems that they do. we all have some degree of insulin and leptin resistance, some degree of vascular damage, etc.; we all age the same way, and what would be best for them would be best for us all, not just for diabetes, heart and vascular disease, excess fat loss, and even cancer, but to treat what I feel very robust science is showing to be a major root that helps to determine the rate of aging itself...nutrient sensing hormones tying into allocation of energy and genetic expression of maintenance and repair vs. cellular reproduction. After testing many hundreds of insulins and leptins, I have found my diet to be the best at keeping these major nutrient sensing hormones low.

As far as protein, I saw quite clearly when I started treating diabetics,that high protein would not lower blood glucose near as much as higher fat. Later, it has appeared clear that a high protein diet would elevate the other major nutrient sensor, mTOR, inhibiting benefits of caloric restriction, and possibly contributing to cancer. I introduced this concept in a talk I gave perhaps now over 5 years ago... http://www.meandmydiabetes.com/2010/05/07/ron-rosedale-protein-the-good-the-bad-and-the-ugly/

I believe that what I have been recommending now for 2 decades, a low non-fiber carbohydrate, higher fat, moderate protein to meet needs only diet, is being shown to be the best and healthiest diet. Newer science including that of leptin, mTOR, and the biology of aging only has served to support this. The other original low carb approaches have all seemed to modify their original recommendations to more approach mine.

I am being told "to turn off all electronic devices" for our landing, so I'll perhaps comment more later. Thanks for the interest.

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Limiting saturated fat for 3 weeks seems like an interesting idea and worth a go if it could help in improving insulin sensitivity. Plus you still get to eat some fat in the form of MCTs. Kruse likes the MCTs as well. – Sue Nov 6 at 23:43
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I actually love MCT. lol – The Quilt Nov 7 at 0:52
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Wouldn't a protocol that decreases leptin decrease overall satiety as well, assuming the person's arcuate nucleus or whatever is getting the signal? Doesn't carbohydrate restriction artificially decrease the hypothalamus' perception of energy (in the form of fat) stores? – Travis Culp Nov 7 at 16:41
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Actually this is not true when you do the reset. We cant single out carbs alone. It has to be put in context of the concominant protein and fat intake. When you do the reset people are shocked at how their cravings and satiety get demolished sans carbs. This is how we use the nucleus of the solitary tract of the vagus to reset the hypothalamus. – The Quilt Nov 8 at 12:28
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In lean people, leptin levels are important. Drops in leptin are correlated to increased hunger with weight loss, leptin scales with bodyfat... it would be pretty stupid of the body to evolve an anti-starvation hormone if the circulating levels of that hormone weren't important. – conciliator Nov 8 at 14:58
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What it really distills down to is this; if a diet or nutritional protocol allows one to better burn fatty acids or ketones as a primary fuel, then it is likely to be quite healthy. If it forces one to burn glucose, then it is not. Eating more protein than necessary for maintenance and repair, thus allowing for gluconeogenesis, glucose burning, and elevated mTOR will not be healthy.

Eating easily burned shorter chain saturated fats is great,. Eating longer chain harder to burn saturated fats when one is not adapted to burning them, will not be so good.

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Dr, are you aware of any study that explores if ketosis can be stopped or prevented by consuming too much protein ? – majkinetor Nov 7 at 9:15
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And how do you explain your usage of fish oil. DHA is the longest PUFA, and it induces oxidative stress more then anything else, at least in theory. clinsci.org/cs/108/0245/1080245.pdf – majkinetor Nov 7 at 9:22
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I also wonder, why are you so low on Vitamin C (1000mg per day). We know that if its going to be effective, you need to at least split the dosage, if not use bigger. Yes, its still 10x larger dose then RDA but since I doubt you are concerned about RDAs, I wonder did you miss this anti-aging option or did you intentionally do it. – majkinetor Nov 7 at 15:05
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I'm in agreement with Rosedale on the sat fats but would say it's probably a good idea while you're losing weight at any sort of clip. Why? However I disagree on the reason (although in his interview with Jimmy Moore his explanation was closer to my thinking). A large portion of our body fat FA's are LCSFA so they are not in short supply. Eat more, burn less of your endogenous supply. Once your fat metabolism has been corrected the composition of your fat consumption won't make much difference, and perhaps some sat fat may be more beneficial. – Evelyn aka CarbSane Nov 8 at 18:48
likey carbsane... need to go find that interview... – Mallory Nov 9 at 17:33
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What these two different approaches have in common is a total lack of supporting science. And yes, when you are bucking so-called "conventional wisdom" and interested in being about science and not opinions, or touting how you are bridging the gap between science and medicine, you better darned well bring it. In Rosedale's case, he says carbs "spike" leptin and this leads to leptin resistance. This is demonstrably false. Leptin is not "spiked" by dietary intake of any macronutrient. He is also of the mistaken belief that consuming carbohydrates causes insulin resistance, when the opposite has been shown to be the case time and again in controlled metabolic ward contexts where the results can be verified. In Kruse's case, I've yet to see any explanation for his arbitrary recommendations. Big protein breakfast? Does this timing and high protein intake alter leptin receptor responsiveness? No snacking? Same question. How do you know you've healed your broken receptors? What epigenetic switches is he talking about and on what levee in Kruse-terroir can we find out what tests he does and how they are interpreted in the context of leptin? There actually is some science out there linking high protein diets with improved leptin sensitivity, but one comes across these things not because of but in spite of Kruse's claims. IGF-1 is a negative in his Quilt Survivability equation, WTF one makes of that!

In his response to Paul Jaminet, Rosedale's own references failed to support his absurd notion that we are all diabetic. Yes, it is absurd. The mortality rates were lowest with fasting glucose levels flirting with a prediabetes diagnosis in one study he used to state his case. There were no differences in all cause mortality for the bottom 90% of subjects in 2hr glucose in another. But at least he puts up relevant cites (for the most part) rather than sending you out to do your own homework to substantiate his claims rather than at least listing one or two from which he developed his theories.

Both of these plans will work for some for the same reasons any low carb plans work for some, or a restrictive plan of any sort works for some.

As for longevity, well, I don't see how having the metabolism of an aging person (e.g. becoming an insulin resistant, lower RQ fat burner) will enhance lifespan. And speaking of age, I'm sorry but as with Dr. Davis, I'm just not seeing some sort of youthful vitality in these folks that I don't see in many of my carb-eating friends of presumably similar age. How old are these guys anyway? I'm not saying they look old or young or whatever, they just don't look any different. And if this metabolic slowing with age is somehow protective and life extending, how does one explain these ROSsified, carb burning nonagenarian spring chicks??

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I can't bring myself to use looks to evaluate anything. Mark Sisson ran thousands of miles and supposedly ate like crap most of his life, and looks freaking incredible at age 58. (This is not disagreeing with you, just another opportunity to wonder where Sisson has found this fountain of youth) The one thing that bar none seems to affect the way you look as you age is chronic stress. – Kamal at PainDatabase.com Nov 8 at 14:27
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I happen to agree Kamal. Most who meet me -- including both my young classes (I'm older than most of their Moms) and older classes (I teach a lot of those returning to school in their 40's, 50's and older these days) -- generally place me at around 10 years or so younger than I am. This despite years of that so-called skin ager (tanning) and crappy diet for so many years. I guess my point is that if there's something to this longevity angle, then it should show, right? Rosedale has been at this for 20 years. Davis talks about glycation and wrinkles so ... whassup with his wrinkles? – Evelyn aka CarbSane Nov 8 at 15:25
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Excellent post, Evelyn. Ultimately, the proof is in the pudding. It'd be hard to imagine there being no outward signs of vitality. Sure, you could claim that all of your blood sample metrics are optimal, but that ought to slow the clock down, right? As unscientific as it is, I think as long as someone feels great and has tons of energy all the time from waking until they go to sleep (with plenty of activity, weights etc.), at least their macro ratio is probably fine. I can't replicate that feeling with LC, so I have a hard time believing that longevity gets in the way of vitality. – Travis Culp Nov 8 at 17:07
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Regarding Sisson, I think a great deal of his health is because of his activity, not in spite of it. He supplies his body with all necessary raw materials, eats plenty of carbs and eats a lot of fat and can do that because he's so active. There is no dietary substitute for activity. Evolution has assumed that sedentary=dead so we've never evolved to cope with it. – Travis Culp Nov 8 at 17:09
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Bottom line, you've been at this for 20 years. You claim to bridge the gap between science and medicine. There should be one good review article in your arsenal to substantiate your basic claims: (1) IR is caused by carbs and insulin spikes, and (2) LR is caused by carbs and leptin spikes. C'mon ... humor me and cite just one of each for me, OK? That is not asking for much. – Evelyn aka CarbSane Nov 9 at 22:23
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They both have a lot of great things to offer the standard american dieter, however I have a couple of issues with Dr Rosedale's protocol....

DON’T BE AFRAID OF FAT--BUT EAT GOOD FAT This is a high fat diet, so if you are hungry, you may eat fat! But stick to the good fats found in nuts, avocados, fatty fish, olives, etc.

Nuts? I don't know anyone who actually thrives on nuts, they seem more like a food people enjoy and eat as many as they can without having trouble.

LIMIT SATURATED FAT FOR THE FIRST THREE WEEKS When you want to lose weight, what you really want to lose is saturated fat. So stop eating it, at least for the first three weeks you are on the meal plan. Pass on the beef, pork, lamb and most dairy products and eat primarily fish, nuts, chicken, vegetables and no fat cheese. After the first three weeks on the meal plan, you can eat foods that are higher in saturated fat (such as lean beef, lamb and pork) although those wishing to continue losing weight should not eat very much of these foods.

I think those wishing to lose weight can eat lean beef, or any kind of beef for that matter. Also, people that are all of a sudden giving up grains/starches/etc might have a hard time feeling satiated without red meats and sat fat... And I'd have an issue with telling someone they can eat low fat cheese.

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Melissa, if sciency language is a problem, I suggest you to get back to the kitchen. – majkinetor Nov 7 at 9:51
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I bet you guys wouldn't be upvoting if I made fun of Dr. Rosedale for being a man or being old. My gender, like his age, has nothing to do with my arguments. Kitchen jokes are funny once, but they keep cropping up around me here and they've just gotten mean-spirited and annoying. – Melissa- huntgatherlove.com Nov 8 at 1:41
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FYI as of right now, majkinetor has been banned from PaleoHacks for abusive & aggressive behavior. – Patrik Nov 8 at 2:21
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Good job Patrik. Melissa I'm really sorry you were attacked like that. Misogynists suck. – Shari Bambino Nov 8 at 3:43
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I find it hilarious that someone who pointedly fingered only older people at AHS as having red faces, and therefore dietary problems and referred in a thread on PH to Fred Hahn having an "alcoholic" red face is getting arsed about a kitchen comment! And then there's the "healthy eating beautiful people" thread where Patrik lost no words in essentially calling Shari an ignorant dufus. Abusive? Aggressive? Mean spirited? Sexism? Ageism? Erm, whatever is the difference, pray tell? Yes, delete my profile. – Atkins-witha-loincloth Nov 8 at 4:18
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The major difference between my program and others, is that it was initially designed to treat the deeper roots of the chronic diseases of aging such as diabetes and heart disease, and it does this extremely well. Getting to the roots of disease reveals that all disease is a disease of communication, particularly of insulin and leptin.Treating symptoms will only serve to increase the wealth of pharmaceutical companies while making people more sick. Diabetes is not a disease of blood sugar but a disease of telling sugar what to do. Osteoporosis is not a disease of calcium. People with osteoporosis have lots of calcium in their arteries. It is a disease in telling calcium where to go. Heart disease is not a disease of cholesterol. Every living cell membrane requires cholesterol.

However, attitudes such as Masterjohn's and Mellisa's below who laugh at the notion of everyone being somewhat diabetic arise from misunderstanding and ignorance of the true underlying roots of disease. It is not “hilarious” that this sort of attitude is killing millions of diabetics treated with drugs and diet that worsen insulin resistance, and killing millions more with other chronic diseases.

As I have said for 2 decades and here several times, and I will repeat and keep saying until properly heard; diabetes is not a disease of blood glucose; it is a disease of hormone signaling, especially leptin and insulin. Chris and Mellisa, like everyone, has some degree of leptin and insulin resistance, and therefore some degree of the major underlying root of diabetes and other diseases of aging, and should be treated as such; the sooner, the better...

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"everyone" is quite a sweeping statement to make. – Matthew Nov 7 at 23:35
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Your perspective does seem at odds with ancestral health and evolutionary biology, but responding to you with snarky anti-intellectualism isn't shedding any light on matters. – Alex Nov 7 at 23:50
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@Matthew: You don't understand - to Rosedale, diabets is model for aging and 'disease of aging' is actually disease of 'leptin and insulin resistance' ? So yes, since everybody ages everybody is diabetic in this model. – majkinetor Nov 8 at 0:41
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Let's fund a study: PHD vs. Rosedale protocol and see where the numbers stack up. So far your study had sick people in it, so obviously their numbers are nothing compared to the Kitavans. Either way, we have no data showing the Rosedale protocol is superior for anti-aging compared to other dietary models in healthy individuals. – Melissa- huntgatherlove.com Nov 8 at 0:54
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Dr. Rosedale keeps repeating that he views the hormonal problems associated in the body as "mis-communication"...they are simply not being heard properly. We have to re-establish proper communication to re-establish health. Whenever Dr. Rosedale speaks, some people seem to be "Dr. Rosedale resistant". He keeps saying the same thing over and over yet it is not getting through. How do we increase sensitivity to Dr. Rosedale's message? I am pondering... – Andre Chimene Nov 8 at 6:14
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I agree with Dr. Rosedale on this. I think the abnormal has unfortunately become the norm. One world famous endo commented to me that it is "normal" for the A1C to rise with age. Why would it be "normal" absent a change in diet? If the anything under 6 A1C is so normal, then why does diabetes expert Dr. Richard K. Bernstein see so many so-called normal people suffering from what are usually termed diabetic complications and neuropathies etc? I wonder if the ever rising A1C is only "normal" after poor fetal programming (obese diabetic mothers, toxemia etc) followed by poor infant diet (soy and sugary frankenfood baby "foods") followed by decades of excessive and highly addictive carbohydrate and sugar overloads and far too little excercise followed by disrupted circadium rhythms and lack of sleep, our addictions to computers/blue light, overwork and sky high stress hormones etc etc etc...I think it's true that most people under 30 can eat loads of crap and still have great labs. But maybe it's just the calm before the diabetes storm. When the storm hits may vary depending upon how much an individual was exposed the the aforementioned factors. I think there is a big problem with docs just looking at fasting glucose because by the time that gets into the diabetic range, there are years of too high but undetected postprandial sugars. Docs won't order A1C unless fasting is high. The high postprandials go undetected. Absent a virus or autoimmmune attack -- diabetes doesn't just happen overnight but that's how it seems when docs only rely on a yearly annual fasting glucose. Now diabetes is huge business -- the testing strips cost a fortune-- ditto for the drugs and even if it's "covered" by insurance -- society pays. Meters in all kinds of colors have become virtual fashion accessories. The ADA is largely a menace in my view.

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Now we got our guns aimed in the right direction...like the march on Wall Street we must march on the ADA. – Andre Chimene Nov 8 at 6:17
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Rosedale protocol will do the job simply because its very limiting and if you limit your food choices you gradually lose weight because you are not hungry for the same food constantly. Its hard to sustain on negative side. Limiting carbs will do the job for majority of people but he also limits SFA in the beginning to speed up things (I guess this is part of propaganda and not crucial part of weight loss, people like to see results fast). No snaking of junk foods but binging on nuts has additional role of providing good source of nutrition with virtually no down sides and lots of magnesium to combat ins. resistance.

Array of vitamins and other supplements will cover most of the eventual malnutrition.

Similar protocols that are not that limiting work equally well, I think. Supplements he recommends are probably responsible for good part of the success.

For most people, I think SFA, protein and vegetable restriction are not important that much and results will be equally good and much more sustainable. Perhaps some people who can't loose weight no matter what they try could try his protocol in full.

Most of the other points are good, like slow eating and exercise after dinner.

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Good point, Maj, if I wanna lean out I stick to three foods: bone broth, yams and green tea. That's it. Amazing how these three just suppress my hunger. Ho hum is my appetite and that's how all indigenous people around the globe survived on: limited foods that are nourishing nonetheless. – Namby Pamby Nov 6 at 18:53
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Maj pretty soon I will unload a new blog covering what to do post leptin Rx after the reset occurs. I think you maybe surprised at what changes I advocate. – The Quilt Nov 6 at 22:07
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I don't feel rosedale is limiting, just because you take out no fiber carbs and fruit.. i eat a lot, and a massive variety.. The supplements help for sure speed up the process of burning fat but I have seen many do it on a tight budget and only have magnesium, potassium and fish oil and they have done fantastic. He does love nuts for sure, but he does say 8-10 nuts in an hour and if you are still hungry have the same again after an hour.. so he does not recommend binging on them.. though if i leave the bag open by my computer it is hard to stop at 10.. – Fiona Nov 7 at 8:35
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Yes, in theory its not binging, in practice it becomes binging. However, I didn't find it to be a problem. I lost 25kg by eating nuts whenever I wanted. They induce satiety quite fast for some reason.... – majkinetor Nov 7 at 9:16
I don't feel rosedale is limiting, just because you take out no fiber carbs and fruit : You don't take just fruit and 'no fiber carbs', but non MCT SFA, and any excess protein, which is quite a lot then. – majkinetor Nov 7 at 9:24
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The Quilt also places importance on breakfast.

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Its huge......... – The Quilt Nov 6 at 22:07
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Tim Ferris also recommends eating within half an hour of waking. His father did it and it jump-started weight loss. He recommends 30g protein. – Sue Nov 7 at 0:11
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Nice reminder that the one-person experiment may (key word: may) hold promise for others. Thanks, Sue. – Dorado Galore Nov 7 at 3:56
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Jack: you probably cover this elsewhere in details, but: assuming absence of leptin issues has been demonstrated for a given individual, that individual proceeds with Berkhan's 16/8 IF protocol, no food between 9pm today and 1pm tomorrow. That's "no breakfast." does this raise concerns from your perspective and your experience? – Dorado Galore Nov 7 at 16:18
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true .....I think my position post Leptin RX will clear up some misconceptions here. – The Quilt Nov 8 at 4:00
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Can anyone else spot the Gen Y peeps and their lack of appreciation that some, in any, if not all communities, industries, fraternities, clubs, think-tanks have forgotten more than they currently know? All must understand where the movement has been to do the same for where it is at. This constant narrow mindedness and quick from the hip smack downs are not adding to a debate but a limiter to growth. By all means question. Be more careful to dismiss so quickly. You can never fast track experience.

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Nice dude, nice.... – majkinetor Nov 8 at 9:29
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Does anyone else see the irony in this comment? – Beth-WeightMaven Nov 8 at 13:03
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Oh please! Quilt claims his goal is ultimately to change his profession. I don't see how routinely dissing them accomplishes that goal. Or posting here, this bastion of discourse amongst MD's, for that matter. – Evelyn aka CarbSane Nov 8 at 14:07
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And you know that he is wrong...same/same. – Andre Chimene Nov 9 at 5:54
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Let 's consider it progress to have a critical mass of gurus and followers pulling in generally the same direction. I don't think there is goingto be THE answer for everybody anyhow. Throwing arrows at each other is not progress; civilized discorse and ealthy disagreement is the way to go. – AdrianaG Nov 9 at 7:08
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Neither is much good if you're not and have never been fat, I have to say.

ETA: Most of these recs will produce fat loss in people of any size. If you don't have fat you can afford to lose you have to modify significantly.

To single out a few, if I want to maintain my weight/build muscle and not feel like shit I've found it necessary to do the direct OPPOSITE of: avoiding starch, eating small meals, limiting saturated fat, eating only to satisfy hunger, eating small meals, not eating before bedtime, eating slowly, exercising after your last meal and before bed.

ETA2: By 'fat' I did not mean obese or very large; I should have said 'high body fat percentage' or even 'not lean'. This applies to most Americans no matter if their BMI is 19 or 40.

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I think their are many normal people that are quite interested in longevity. That has always been my focus. So again your perception does not meet my reality. – The Quilt Nov 7 at 0:54
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To single out a few, if I want to maintain my weight/build muscle and not feel like shit I've found it necessary to do the direct OPPOSITE of: avoiding starch, eating small meals, limiting saturated fat, eating only to satisfy hunger, eating small meals, not eating before bedtime, eating slowly, exercising after your last meal and before bed. – animalcule Nov 7 at 1:15
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Wt loss is irrelevant. Mine is a program to extend youth,therefore health. I began my program to treat deadly disease, and from my interest in the biology of aging. As such,it was imperative to control insulin,later leptin, and later mTOR. Being able to easily burn fat is a necessary condition for all health and longevity.This results in loss of extra fat,but not weight loss per se. It turns out to be an excellent fat loss diet, because of the common roots of chronic disease. It is very common,if not usual,to gain lean mass on my program secondary to the improvement in insulin signaling. – Ron Rosedale M.D. Nov 7 at 6:23
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Body comp is all about the biology of the leptin receptor – The Quilt Nov 7 at 14:41
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Cate Shanahan talked about adipocyte apoptosis in her podcast with Jimmy Moore. I'm hoping she's right! – Beth-WeightMaven Nov 9 at 13:27
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2000 views in 2 days? This has become like the Colisseum. Ler's throw them to the lions.

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