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My question has to do with someone who develops leptin resistance. It's been said that one way to tell if you are leptin resistant is to look in the mirror because you'll have gained significant body fat. But isn't it also true that leptin resistance leads to insulin and then cortisol resistance? If this is happening to that person their cortisol levels will be elevated, and cortisol increases visceral fat but decreases peripheral fat. So could it be possible that there are a significant number of people with leptin resistance who don't look largely overweight for this reason? Or is the rate of fat accumulation from this person's inability to burn it greater than the rate at which even elevated cortisol levels break down that fat? Or, does this person eventually have adrenal burnout resulting in low cortisol levels and if so how common is this?

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"it's been said"...by whom? – texasleah Nov 29 2011 at 21:58
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What people say is not always worth listening to. – Matt Nov 29 2011 at 22:10
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I know Dr. Kruse has said that and I remember some other users here mentioning it in various posts. – Chris Antenucci Nov 29 2011 at 22:12
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They say that in 'Mastering Leptin' as well – Jeff Nov 30 2011 at 0:24

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When I started, the mirror told me I had a lot of weight (proportionately) around my middle. In the last 90 days, I've lost 4 inches off my waist and I'm acting much more leptin-sensitive.

I think you can hide a little visceral fat in any gut, but you won't hide much in a small lean middle. In my case, when I clench my ab muscles it seems like there's not much mass under the fat so I'm guessing I don't have a ton of visceral fat.

For example, if the "hard" part of your gut extends above your hips or ribs when you're lying down on your back, there's got to be a lot of visceral fat. In my case, the hard part is well below the level of both.

I'll look forward to more technical answers to your question, which is a good one. Thanks!

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Thanks for sharing your experience Nance. I guess an additional part of my question I should've mentioned is that since cortisol also breaks down muscle protein should people focus more on lack of muscle rather than body weight, or again is this irrelevant if cortisol levels don't remain elevated in someone with leptin resistance? – Chris Antenucci Nov 29 2011 at 22:28
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Hmm, I see and I can't help you with that. Lack of muscle is not my problem, though, leptin resistant or not. For some reason, exercise=muscle-tone for me despite my age. – Nance Nov 29 2011 at 22:36
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This is really interesting because part of the leptin reset is to do Hiit training - but will hiit training or even weight training drain your adrenals even more if you are past leptin and have Adrenal fatigue?? Given that weight training increases cortisol levels??

I have been reading on Adrenal Fatigue and some state that 80% of people who are overweight have it - but I think I disagree. 80% of the people who are overweight I would say that 50 - 60% can lose the weight if they worked at it but there seems to be a few of us that we need to dig deeper than diet and weight training to lose the weight - I wonder if that's the group that has adrenal burnout?

I would like to be clearer in my head with the science of leptin/cortisol. I personally what to get better and dont know how to

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That's a good point, and there's a good chance that if you can't lose weight you are leptin resistant, especially if your diet is low in sugar. Check out Dr. Kruse's blog and his articles on leptin www.jackkruse.com. He has the most research I've seen on leptin. – Chris Antenucci Nov 30 2011 at 0:39
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Thanks Chris I have been following him I just wondered as the only thing he addresses with leptin resistance and Adrenal exhaustion is not to over work the body - I have to ask myself if Hiit is overworking my body? – Vivalapaleo Nov 30 2011 at 2:13
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I just posted a comment to Judy on my last blog that addresses this. It is comment 48. I treat adrenal fatigue with light as a first line treatment – The Quilt Nov 30 2011 at 3:19
Thanks Jack - will try that - 3 weeks - wow I will be so happy if thats what it takes ! – Vivalapaleo Nov 30 2011 at 5:18

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