First off, I believe in eating fruit. I am coming to question eating sugar and sweet liquids.
I've been very curious about fructose since viewing the video from Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology. Some of the takeaways from this video are that Fructose is bad. Fructose is digested mostly in the liver. Somewhere around 30% of the food energy from fructose goes right into fat stores from the liver. It also results in increased uric acid output, which makes you more likely to get gout and hypertension. Increased uric acid output increases blood pressure. Eating fructose also suppresses Ghrelin, which causes you to be hungry.
Here are some articles about fructose increasing blood pressure. The mechanism is that fructose is processed in the liver. The liver emits more uric acid as a result. Increased uric acid output raises blood pressure. They have also shown that
lowering uric acid levels also lowers blood pressure
Fructose consumption increases appetite. As Dr. Robert H. Lustig says in the video above, Fructose suppresses Ghrelin. Ghrelin is the signal that is supposed to tell your brain that you are full. Suppressing that signal increases your appetite.
This article from The Journal of Clinical Endocrinology & Metabolism says some of the same things:
"Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women"
This appears to be another way that Fructose increases your appetite:
"Fructose Metabolism By The Brain Increases Food Intake And Obesity, Review Suggests"
I'm puzzled by this article, because previously, we've read that normal cells in your body don't metabolize
fructose directly, the liver has to do it.
I don't need my appetite increased, it is already too large already!
Even though normal cells in your body can not metabolize fructose directly, it appears that cancer cells can metabolize fructose to speed cancer growth!
"Pancreatic tumor cells use fructose to divide and proliferate, U.S. researchers said on Monday in a study that challenges the common wisdom that all sugars are the same."
"They said their finding, published in the journal Cancer Research, may help explain other studies that have linked fructose intake with pancreatic cancer, one of the deadliest cancer types."
"While it's widely known that cancer cells use glucose to fuel their growth, last week's findings were the first to link fructose to cancer growth. The cancer cells grew at fructose concentrations easily attainable in our North American diet and they did so at a similar rate to glucose.
However, the data showed that cancer cells used fructose and glucose in very different ways, even though they are structurally similar. Compared to glucose, fructose was a potent activator of a key cellular pathway that drives cancer cell division.
Not only did cancer cells prefer fructose, the sugar also triggered cellular activities that enabled malignant cells to use both glucose and fructose more rapidly."
The Wiki on Fructose and sucrose are interesting reading, too:
The Entries for "Liver Disease', 'Digestive Problems", "Metabolic syndromes", and "Gout" are food for thought. What it does to your liver sounds nasty.