Can eating paleo modify our epi genome making us younger as we get older? in worm studies, caloric restriction reduces insulin to increase lifespan. In Paleo man carbohydrates and not calories are restricted but because the hemoglobin A1c levels are much lower i suspect insulin is also reduced mimicking starvation. i suspose time will tell.
What we eat and do in this lifetime will change our personal outcomes, but I'm dubious of an effect on personal genetics, which would affect our descendants rather than us. I agree with anonymous that we can increase our longevity most by taking action to reduce chronic risks. Control of obesity doesn't require genetic modification.
It's a good question, Evzone. You might find some good discussion in some other threads here on the topic. Clicking on your tag "longevity" brings up some good stuff.
I believe that it's pretty clear that addressing the things that we know are killing us, such as heart disease and diabetes, through diet and lifestyle, will result in increased quality and quantity.
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