I have read about this stuff called deer antler velvet and it sounds too good to be true. It seems to be something real from the antler of a male deer and nothing added. Just wondering if anyone has tried it and if so what was your experience. thanks.
Ive been hearing about this stuff too. Here what I found, mostly regarding nerve regeneration/protection.
"Deer Antler is rich in Neurotrophin-3 and IGF, which is a player in nerve remyelination." ----Dr. Anthony G. Payne
Brain Res. 2003 May 16;972(1-2):110-8.
Neurotrophin-3 specifically increases mature oligodendrocyte population and enhances remyelination after chemical demyelination of adult rat CNS.
Jean I, Lavialle C, Barthelaix-Pouplard A, Fressinaud C.
Cell Biology Laboratory, UPRES EA 3143, University Hospital, 4 rue Larrey, F 49033 Angers cedex 01, France. email@example.com
In human central nervous system (CNS) demyelinating diseases, spontaneous remyelination is often incomplete. Therefore, we have tested whether neutrotrophin-3 (NT-3) accelerates CNS myelin repair after a chemically-induced demyelination. One group of adult rats was injected in the corpus callosum (CC) with 1 microl of 1% lysophosphatidylcholine (LPC) and 1 microl of NT-3 (1 microg/microl), and 15 days after injury (D15) remyelination was compared to control rats (receiving 1 microl of LPC+1 microl of vehicle buffer of NT-3). The demyelinated volume decreased by 56% in NT-3-treated rats at D15, and immunohistochemistry showed an increase in mature MBP(+) oligodendrocytes (OL) (+66%) in treated animals (whereas less mature (CNP(+)) OL were unchanged). Since less than 3% axons degenerate in this model, and as astrocytic gliosis was not modified, these data suggest that NT-3 acts directly on cells of the OL lineage to enhance remyelination in vivo.
PMID: 12711083 Mol Cell Neurosci. 2002 Feb;19(2):239-49.
Neurotrophin-3-mediated regeneration and recovery of proprioception following dorsal rhizotomy.
Ramer MS, Bishop T, Dockery P, Mobarak MS, O'Leary D, Fraher JP, Priestley JV, McMahon SB.
CORD (Collaboration on Repair Discoveries), The University of British Columbia, Biosciences Building, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada.
Injured dorsal root axons fail to regenerate into the adult spinal cord, leading to permanent sensory loss. We investigated the ability of intrathecal neurotrophin-3 (NT3) to promote axonal regeneration across the dorsal root entry zone (DREZ) and functional recovery in adult rats. Quantitative electron microscopy showed robust penetration of CNS tissue by regenerating sensory axons treated with NT3 at 1 and 2 weeks postrhizotomy. Light and electron microscopical anterograde tracing experiments showed that these axons reentered appropriate and ectopic laminae of the dorsal horn, where they formed vesicle-filled synaptic buttons. Cord dorsum potential recordings confirmed that these were functional. In behavioral studies, NT3-treated (but not untreated or vehicle-treated) rats regained proprioception. Recovery depended on NT3-mediated sensory regeneration: preventing regeneration by root excision prevented recovery. NT3 treatment allows sensory axons to overcome inhibition present at the DREZ and may thus serve to promote functional recovery following dorsal root avulsions in humans. (C)2002 Elsevier Science (USA).
PMID: 11860276 [PubMed - indexed for MEDLINE]
In studies, Vitamin D has been found helpful against autoimmunity for the down-regulation of Th1 and up-regulation of Th2 cells. It has also been shown to regulate the neurotrophins NGF (Nerve Growth Factor), NT-3 (NeuroTrophin 3) and NT-4. In addition, D3 has also been found to promote differentiation and cell death in neuroblastoma (brain tumour) cell lines as well as cancers in general making it a possible weapon against tumours.
J Mol Endocrinol. 1997 Oct;19(2):173-82.
_Expression of neurotrophin-3 in the growing velvet antler of the red deer Cervus elaphus.
Garcia RL, Sadighi M, Francis SM, Suttie JM, Fleming JS.
Department of Physiology and Centre for Gene Research, Otago School of Medical Sciences, Dunedin, New Zealand.
Antlers are organs of bone which regenerate each year from the heads of male deer. In addition to bone, support tissues such as nerves also regenerate. Nerves must grow at up to 1 cm/day. The control of this rapid growth of nerves is unknown. We examined the relative _expression of neurotrophin-3 (NT-3) mRNA in the different tissues of the growing antler tip and along the epidermal/dermal layer of the antler shaft of the red deer Cervus elaphus, using semi-quantitative reverse transcription-polymerase chain reaction. _Expression in the tip was found to be highest in the epidermal/dermal layer and lowest in the cartilaginous layer in all developmental stages examined. These data correlate well with the density and pattern of innervation of these tissues. Along the epidermal/dermal layer of the antler shaft, _expression was highest in the segments subjacent to the tip and lowest near the base, arguing for differences in the temporal _expression of NT-3 in these segments. The _expression of NT-3 in cells isolated from the different layers of 60-day antlers did not mirror that observed when whole tissues were used and may suggest regional specificity of NT-3 _expression within antler tissues.
PMID: 9343309 [PubMed - indexed for MEDLINE] J Exp Zool. 1998 May 1;281(1):36-42.
Detection of growth factors and proto-oncogene mRNA in the growing tip of red deer (Cervus elaphus) antler using reverse-transcriptase polymerase chain reaction (RT-PCR).
Francis SM, Suttie JM.
AgResearch, Invermay Agricultural Centre, Mosgiel, New Zealand.
Deer antler is a unique mammalian organ that has an annual cycle of regeneration. The antler grows very rapidly from the tip at up to 1 cm/day in red deer for a 90- to 120-day period. It is hypothesised that locally produced growth factors are required to control and stimulate this growth. The tip of the growing antler from animals whose antlers had been growing for 30, 60, or 90 days was dissected into four zones: epidermis/dermis, reserve mesenchyme, precartilaginous, and cartilaginous. Total RNA was extracted, and the presence of various growth factors and proto-oncogenes was detected using RT-PCR, IGF-I, IGF-II, TGF beta 1, TGF beta 2, c-fos, c-myc, and beta-actin were all present as single bands of the expected molecular weight in the four zones of the antler at each stage of growth. There were higher levels of IGF-I, TGF beta 2, and c-myc relative to beta-actin in the epidermis/dermis layer than in the other three zones. There were no differences in the _expression of any of the genes between the three stages of growth. The presence of TGF beta 3 cannot be confirmed since multiple bands were seen in all antler tissues. A single band of the expected size for TGF alpha was seen only in the epidermal/dermal layer of the antler, with multiple bands of different molecular weight being detected in the other zones of the antler. This work has demonstrated the presence of multiple growth factors in the growing deer antler and supports the hypothesis that paracrine/autocrine stimulation is important for regulating antler growth.
Yeah it's one of my favorite supplements/herbs to take! I literally JUST uploaded a video about it today too. If you're interested you can watch it here:
I have used it for joint repair in myself as well as a good anabolic booster to workout regimens. I've seen impressive results in friends who have taken it and healed at ridiculous rates to things like broken femurs and skin burns etc.