I haven't listened to the podcast, but I have a comment anyway.

I think there is definitely a problem with a medical approach that considers a condition recognizable only when it is past the point of fixing with gentle measures, so that you go from normal to Addison's, with nothing in between. That's obviously wrong, and there are probably people suffering in the purgatory of adrenal fatigue for a long time without help.

The big problem I see about it partly comes out of this fact that the medical community doesn't recognize it. Therefore people who are experiencing it, or developing theories about it are relegated to the fringe. This gives it a disadvantage, because they cannot then go and get studies funded that would test the appropriate measures to find out what is true and what is not. So what we are left with is a haphazard combination of people's best guesses about what is happening, combined with wisdom gleaned from anecdotes, some of which is likely to be true, and some of which is likely to be false.

Finally, a problem like adrenal fatigue is characterized by a host of common symptoms that could have any one or more of a multitude of causes. Tiredness? Disturbed sleep? PMS? Everything causes those things! So what happens is that a thousand desperate people think they have adrenal fatigue. Maybe they do, but it only adds to the confusion and general sense that it is just a theory.

For example, if you suspect you have AF, you are encouraged to take a 24 hour salivary cortisol test. But what if your test results aren't normal? There could be multiple reasons for it. To say that this is a definitive confirmation of someone's proposed mechanism of AF, well, that's hubris.

I fully expect that over time we will recognize something like adrenal fatigue, and have real clinical experience to guide the treatment, but what I see right now is full of hypothesis and black magic (some of which is probably correct, but we can't evaluate it), and so I'm not surprised it isn't taken seriously.

Jimmy Moore has a lot of people on his show. Doesn't mean they're right or wrong. You can't take what they say as gospel. You have to verify/validate it and see how it works with your own knowledge on which way you'll go.

In terms of his adrenal fatigue comment, take a look and see if there are multiple non-vegans advocating it. If there are, then he's disproved.

having lived an extremely stressfull life full of depression and anxiety, eating disorders, hyper activity, allergies and hypersensitivity to food and environment and now being a 29 year old female who has the hormonal level and adrenal function of an 80 year old, i would say adrenal fatigue sure feels real when i fall asleep in so much pain from my hips or want to hike and run like i used to but can barely move one foot in front of the other.