I've been having some rosacea issues recently and suspected it was due to gut problems, like SIBO or something pathologic somewhere in the G.I. tract The SIBO result (from a separate test) was positive, with mild bacterial overgrowth. I've been fairly strictly paleo for three years, but have a history of antibiotic use for acne.

My results from the CDSA 2.0 were mostly maddeningly normal - plenty of Bifido and Lactobacillus bacteria present, good fat distribution, pancreatic enzymes, etc. The exception was beta-glucuronidase, which was sky-high. Reference range is 337 - 4,433 U/g, and my result was 28,746 U/g. This didn't seem to bother my PCP, who talked about it being a problem if it was low but nothing really if it's high. That seemed kind of hinky to me.

From a bit of digging I find out that high BG can sabotage one of the main detoxifying mechanisms in the body. Specifically, the liver binds different "toxins" and hormones with glucuronic acid and releases them in the bile to the intestines to be excreted. The BG unbinds these toxins meant for excretion and sets them free to be recirculated in the enterohepatic cycle. Sounds like bad news to me and seems like it could account for some skin problems if substances that should be leaving the body are being recirculated, exacerbated by bacterial overgrowth in the small intestine.

Or this is all crap, no pun intended, that I've patched together through the magic prism of the internet. Which brings me to my question: Has anyone used this test personally or professionally, and do you know how much of a concern high beta-glucuronidase is? It sounds bad, but I wasn't even aware of its existence until about nine hours ago. I'm considering taking calcium d-glucarate, which apparently neutralizes BG, until I can get more glucuronic acid from vegetables and fruits (I'm in a relatively restrictive phase of the GAPS diet at the moment).

Thanks in advance for any of your experiences or knowledge.