Those familiar with the work of Michael Ristow will know that caloric restriction results in dramatically extended life expectancy in C. Elegans. In his studies, he noted that antioxidant supplementation thwarted this effect.
His premise is that CR induces a hormetic effect - via oxidative stress - presumably mediated by endo-antioxidants (superoxide dismutase??). Hence antioxidant supplements interfere by limiting oxidative stress, and short circuiting hormesis.
So - it seems that one should AVOID AO supplements - particularly when following an IF regimen. Comments, please...
It seems too, that AGE production might just be the decisive factor in matters health and longevity, rather than oxidative stress per se, since it looks like the body is able to cope with that. Logically, then, aren't avoidance of fructose, keeping blood glucose levels moderately low, and IF the way to go?
Seems to fit the Paleo approach!
Hey folks - I found my own answers - elegantly researched by Todd Becker.
Take a look if you're interested in this topic, Todd has tackled it in his own inimitable "OCD" style.
Given that whole fruit has always been in our environment, and we may have eaten different species along the way but they were always sweet--as was honey--and that we can not make our own vitamin C I plan to continue eating a piece or two of whole fruit each day. Supplements are manufactured and processed just as junk food is and they are even more highly processed.
I agree that HFCS and eating mass quantities of fruit every day isn't good for you, just as I agree that eating only vegetables is a famine-type diet and eating only meat may just perhaps be a famine-type diet though there are people who swear they thrive on both those approaches.
I subscribe to "don't throw the baby out with the bathwater" and I will continue to eat whole meat, vegetables and fruits. When I was eating a ton of fruit along with HFCS my liver enzymes were just fine--if a couple pieces of fruit can shorten my life on an ancestral eating plan then there's something wrong with the plan.
The AGE thing is definitely real. You only need to look at massive steroid abusers (and I mean, worlds-strongest-man type; big BIG guys) and then google their age (and srsly, wtf) to see the enormous impact of carb-loading.
Not sure about anti-oxidants, but it's an interesting train of thought and I'll definitely do some reading on it.
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