Those familiar with the work of Michael Ristow will know that caloric restriction results in dramatically extended life expectancy in C. Elegans. In his studies, he noted that antioxidant supplementation thwarted this effect.
His premise is that CR induces a hormetic effect - via oxidative stress - presumably mediated by endo-antioxidants (superoxide dismutase??). Hence antioxidant supplements interfere by limiting oxidative stress, and short circuiting hormesis.
So - it seems that one should AVOID AO supplements - particularly when following an IF regimen. Comments, please...
It seems too, that AGE production might just be the decisive factor in matters health and longevity, rather than oxidative stress per se, since it looks like the body is able to cope with that. Logically, then, aren't avoidance of fructose, keeping blood glucose levels moderately low, and IF the way to go?
Seems to fit the Paleo approach!