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Hey there fellow hackers!

I am writing a research paper for my nutrient metabolism class on "high fructose consumption and leptin resistance".

Could you all point me to some scholarly articles or "original" studies dealing with the subject? Specifically regarding FRUCTOSE (HFCS, most likely culprit) and leptin resistance would be great but even if they were studies about sugar in general and leptin that would be awesome too.

Also, science behind "lepting reset" would be helpful as I'm wanting to put in information on what has been found to fix leptin resistance the best.

Thanks in advance!

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3 Answers

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The only models that have shown leptin resistance with fructose are diets that contain 60% pure fructose, an amount that is basically impossible to consume in a normal diet. It hasn't really been shown in human diets either as far as I can find.

"A different form of leptin resistance (in combination with insulin resistance and weight gain) easily arises in laboratory animals (such as rats), as soon as they are given unlimited (ad libitum) access to palatable, energy-dense foods,[62] and it is reversed when these animals are put back on low energy-density chow." http://en.wikipedia.org/wiki/Leptin

This type of leptin resistance is probably more to blame than fructose induced leptin resistance.

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so you are saying that it would be better to look at leptin resistance as a result of insulin resistance? and that the two go together? – boredomkillsya Jan 26 2012 at 20:55
changed my paper to include all sugars and leptin resistance..also going to branch out to talk about obsesity's role in leptin resistance. should be interesting! – boredomkillsya Feb 7 2012 at 2:45
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Also, science behind "leptin reset" would be helpful as I'm wanting to put in information on what has been found to fix leptin resistance the best.

The science behind it is quite complex and contains many moving parts. There are many threads about it on here, I've summed up some of it previously.

http://paleohacks.com/questions/74337/what-is-jack-kruse-aka-the-quilt-right-about/86962#86962

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Stephen Guyenet cites at least two such articles in this blog post. It's worth running a search on Stephen's blog; he's a biochemist who specializes in this type of research.

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 I'm going to do that, thanks! – boredomkillsya Feb 7 2012 at 2:45

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