Does anyone know what the molecular mechanism is behind bovine-derived phosphatidylserine's cortisol blunting effects in response to exercise?
Well thought out detailed theories are welcome too!
Phosphatidylserine is believed to help re-sensitize the hypothalmic-pituitary-adrenal axis to cortisol, thus reducing its overproduction:
There have been limited studies, funded by supplement manufacturers, showing that soy derived PS limits exercise induced stress, however results of the studies are controversial: http://www.med.nyu.edu/content?ChunkIID=21843
Elsewhere on this site (think its the Adaptogens thread) I posted some links to the newly emerging fish derived phosphatidylserine supplements, along with the DHA and/or EPA conjugated forms of soy derived PS. These appear to have chemical strcutures that more closely approximate bovine derived PS. http://paleohacks.com/questions/12136/has-anyone-tried-adaptogens#axzz1ku395h27
Have you read this:
How can cortisol levels be governed? 4 Answers
Phosphatidyl Serine v Cortisol 3 Answers
Cortisol and low-carbs 7 Answers
Cortisol reduction success stories 3 Answers