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I found a couple years ago that I am seemingly gluten intolerant. For example during the holidays when I ate alot of wheat containing foods I was a mess for a week or two. I am generally gluten free but maybe once every other month I might have one or two slices of pizza at work when we order pizza. It is usually a crapshoot how I will feel after that. The same applies to when I was on vacation visiting parents and I might have had a small amount of olive bread, for example. I felt generally fine this time.

Is this just a bad idea to do that or would it be considered hormetic to have a small amount every so often?

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I've been reading about gluten sensitivity a lot and I haven't seen anything to the effect that small doses might be hormetic. In any amount it's obviously poison for me and please note it has been a progressive thing so you could be risking more/worse problems in future. – Nance Feb 10 2012 at 16:11
I agree, I am mainly concerned about celiac disease or otherwise damaging the microvilli in my g.i. tract and risking malabsorption of nutrients, etc. – Kevin W. Feb 10 2012 at 16:29
I was gluten intolerant to where it would take a couple slices of bread to show symptoms. After being completely gluten free for months, just a bite will send me over the edge. – Clint Feb 10 2012 at 21:26

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Kurt Harris has a post directly answering that question: Stress Does Not Imply Hormesis.

Some things, like wheat, probably don't have "mechanisms which where the body's responses leaves you physically 'better off' than before". If wheat is a problem for you, the damaging effects we know about won't be hormetic. Not the cytotoxic T-cell mediated gut response, the cytokines released, the thyroid issues and numerous other inducible auto-immune diseases (especially when intestinal permeability is present), and so on. These are bodily processes produced in an apparent emergency, and they don't appear to make us stronger.

Still, wheat may not be "just a bad idea" either; that depends on the person. Some people probably don't suffer from any of the ill effects of wheat consumption, though this could be the minority and that immunity could be temporary.

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It may have been at one point in history, but with present day wheat I would doubt it.

Would be interesting to know if you could build a tolerance by starting with extremely small doses like you can with other toxic substances (e.g. snake venom).

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I remember on a Robb Wolf podcast awhile back he suggested that soldiers in the field keep some crackers or some other wheat food to eat so that they could tolerate having to eat wheat when there is nothing else available. I'm not sure why this is a good idea. I don't think it is necessary for me to have a tolerance, but I think it can be difficult to be 100% gluten free since it can be hiding in sauces, meatballs, and other places you wouldn't expect. – Kevin W. Feb 10 2012 at 16:28
I always expect gluten in meatballs. It's an integral part of the recipe...that's why I don't eat Italian food. – Futureboy Feb 10 2012 at 17:08
@Kevin W, I don't disagree with your comment about sauces, etc., which is why I only eat sauce/gravy I make myself at home. Whole foods only. – Nance Feb 10 2012 at 20:40

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