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Just a short question on Vit D dose. In Belgium, the only affordable Vit D is one that comes in ampoules of 25.000 IU (€1 per ampoule). In the winter, I usually take about 2/week or 3 in 2 weeks.

I know that the best way to know is to test my Vit D levels, but I'm not really concerned about this. My question is: does it matter if I take it only 2 times per week instead of daily (meaning on days without sunshine?).

My guess is that it doesn't matter that much, since Vit D is fat soluable and for people spending a lot of time outdoors, they also have clouded and sunny days?

Or am I wrong?

Thanks.

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Are you sure this is D3 and not D2? – JJ Sep 8 2010 at 14:15
Yep, cholecalciferol. – Pieter D Sep 8 2010 at 15:09
Pieter, my doctor recommended these D-cure supplements once a week and my level was 9ng/ml... That being said, why don't you buy this stuff on iHerb? If you pick airmail, you can get 360 capsules with 5K IU of D3 for 20$ including shipping. Besides, the vitamin D you're talking about is made with canola oil, while the one from iHerb is made with olive oil : iherb.com/… – Bruno Feb 15 2012 at 15:54

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From Vitamin D Council:

Like most medication, cholecalciferol is certainly toxic in excess, and, like Coumadin, is used as a rodent poison for this purpose. Animal data indicates signs of toxicity can occur with ingestion of 0.5 mg/kg (20,000 IU/kg ), while the oral LD50 (the dose it takes to kill half the animals) for cholecalciferol in dogs is about 88 mg/kg, or 3,520,000 IU/kg. This would be equivalent to a 110-pound adult taking 176,000,000 IU or 440,000 of the 400 unit cholecalciferol capsules.

The standard procedure for people low in D is to give them a huge shot once a week... And as you said, it stores in fat and we use its needed. Those megadoses have been shown to regulate daily levels with a weekly shot, I wouldn't worry about it :)

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thanks, I didn't worry about overload toxicity, more about efficiency of daily versus twice a week. But it's good the see the those numbers. – Pieter D Sep 8 2010 at 13:56
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Haha, that's funny. I think I'm going to take a 1-million IU dose of vitamin D one of these days ... +1 – Paul Sep 8 2010 at 14:08
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One thing to consider is that the human body will naturally taper production of vitamin-D based on quantity of exposure to UV sunlight. As sunlight exposure results in more vitamin-D than is needed, production will drop off and of course melanin will increase skin pigmentation.

This however does not happen with supplemented vitamin-D3.

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Where can I read more on this? – Stephen-Aegis Sep 8 2010 at 22:28
Stephen: Hollick's seminal paper nature.com/jid/journal/v77/n1/full/5615643a.html – Chris Sep 8 2010 at 23:30
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Poliquin is all about a bolus dose of vitamin D for deficient individuals. 30k to 100k IU, twice a week.

http://www.charlespoliquin.com/ArticlesMultimedia/Articles/article.aspx?ID=230

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Poliquin is also selling it, right along side "lean legs fat burning cream for women" – xjhues Sep 8 2010 at 20:42
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What about what time of day to take the vitamin D? Ive been taking it at midday thinking thats when i should be getting sunshine, but Rob Wolfe mentioned in a recent podcast that he takes his later(in evening i think he said), i guess because D created via sun and skin may take time to appear in the bloodstream...

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Eat some polar bear liver :) (google it)

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Oops, that was vitamin A. Sorry! – Scottyb Sep 8 2010 at 19:29

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