Just a short question on Vit D dose. In Belgium, the only affordable Vit D is one that comes in ampoules of 25.000 IU (€1 per ampoule). In the winter, I usually take about 2/week or 3 in 2 weeks.
I know that the best way to know is to test my Vit D levels, but I'm not really concerned about this. My question is: does it matter if I take it only 2 times per week instead of daily (meaning on days without sunshine?).
My guess is that it doesn't matter that much, since Vit D is fat soluable and for people spending a lot of time outdoors, they also have clouded and sunny days?
Like most medication, cholecalciferol is certainly toxic in excess, and, like Coumadin, is used as a rodent poison for this purpose. Animal data indicates signs of toxicity can occur with ingestion of 0.5 mg/kg (20,000 IU/kg ), while the oral LD50 (the dose it takes to kill half the animals) for cholecalciferol in dogs is about 88 mg/kg, or 3,520,000 IU/kg. This would be equivalent to a 110-pound adult taking 176,000,000 IU or 440,000 of the 400 unit cholecalciferol capsules.
The standard procedure for people low in D is to give them a huge shot once a week... And as you said, it stores in fat and we use its needed.
Those megadoses have been shown to regulate daily levels with a weekly shot, I wouldn't worry about it :)
One thing to consider is that the human body will naturally taper production of vitamin-D based on quantity of exposure to UV sunlight. As sunlight exposure results in more vitamin-D than is needed, production will drop off and of course melanin will increase skin pigmentation.
This however does not happen with supplemented vitamin-D3.
What about what time of day to take the vitamin D?
Ive been taking it at midday thinking thats when i should be getting sunshine, but Rob Wolfe mentioned in a recent podcast that he takes his later(in evening i think he said), i guess because D created via sun and skin may take time to appear in the bloodstream...