I've read criticisms of Dr Kruse here and elsewhere for communicating in doctor-speak, acronymns, etc. In this talk, I thought he went out of his way to speak in general terms. There were times I wished he went into more substance for deeper precision but I realize others might not have wanted him to so you can't please everyone.
I agree with his comment that we've "come to the mean" by ensuring that as many individuals survive as possible. I think I disagree with his conclusion that doing so has slowed our evolution; I think it's just as likely we've sped it up because people with many genetic variations have reproduced. Some of those have definitely perpetuated weaknesses that wouldn't have survived "in the wild" but others allowed superior traits to survive despite accompanying weaknesses (think Stephen Hawking.)
I came to attention when Dr Kruse spoke about uncoupling proteins because all my life the guys around me were walking "blast furnaces" while my skin was cool. I was always cold when others were warm despite my obesity.
Hmm. You know, I think my uncoupling proteins were "broken." I'm happy to report that 10 months of quality nutrition have helped and while I'm still not close to radiating heat I'm definitely less cool than in the past.
I'll be willing to read more on his thoughts.