To me one of the most interesting challenges is how fast humans really evolve. On one hand we know that it takes hundreds of thousand years. on the other hand we have studies and proofs that sometimes changes and adaptations may happen much faster, a few thousand years. So what if we did adapt to some aspects of neolithic diet?

other argument might be that we simply can't turn the clock back. Paleo might be great for some individuals, small groups, but is impossible for humanity as a whole. The human population exploded after the agricultural revolution, more and more people could settle and be fed. The lives were of worse quality and shorter, but more of them could be brought to life.

Today's world is overpopulated in terms of paleo diet. we can't just reset the world. Paleo works best when there isn't too many people around...