I lost the first 100lbs doing a high protein / moderate carb / high fiber diet that I made up myself with various tweaks over the five years it took me to lose (and regain some) and lose the weight.
After maintaining at my first goal weight for a year, I went Paleo hoping to work on losing body fat and finally get my weight to a "normal" BMI for my height. In just two weeks, I lost the last 11lbs and dropped 4-6% body fat. Then I slowly raised my calories and fat back up (I track EVERYTHING.) until I was comfortable, but would not see a weight gain.
I was able to raise my calories from 1200 per day to 1400/1500 per day and raise my fat intake to about 50/55% of my calories and have been maintaining fine while doing three days a week of 20 minute HIIT sessions.
Eta: 5'2", 136lbs, 39 and holding. ;) I know the 136 seems high to some for 5'2", but my BF is 22/24% and I fit in size 4s. I'm happy here.