Fructose, in the long run, is nasty stuff. It is a non-essential molecule, and it doesn't matter what source it comes from, it is detrimental. It could be from a nice crisp Fuji apple or classic Coke; once absorbed into the blood stream it doesn't have a label such as "organic apple, I'm okay" it will just do its damage.
Another thing that Dr Lustig contends is very suspect in my mind. He claims that fiber, such as in whole fruits and vegetables, by slowing down absorption of sugars, makes them okay. A few minutes delay to even a couple of hours delay would be expected to make little difference in the number of molecules the body must deal with. And, even when phosphorylated on the first pass through the liver, fructose has become an active triose. There's a slight beneficial effect but it's unlikely to be major protectionprotective effect.
Fructose should really be eliminated from the diet to the greatest extent possible. I have done so for 8 years now, and the health benefits are amazing. I was, at age 60, in metabolic syndrome. On the very low fructose diet I lost 60 lbs, blood pressure went from 145/95 to 115/70, fasting blood glucose went from 95-65 mg/dl, LDL cholesterol dropped 80 mg/dl while HDL went up and triglycerides went down, too. All from simply keeping fructose below 4 g/day. These benefits happened in less than a year and I have maintained them for 8 years, "effortlessly" with no hunger, loss of energy or headaches; just better health. The mentioned effects are very well spelled out in Dr Lustig's lecture on hepatic fructose metabolism. Had that lecture been around I would have expected those effects, but my research was still in its beginning stages then and much of the information he presents has been discovered in the mean time. I was surprised at how it worked on so many criteria at the same time.
I finished transitioning onto a very low carb, limited protein, high fat diet the first of March and the benefits of that: a wonderful feeling of well-being and an increased level of steady energy are great.