I started it less than a month ago due to concerns about peri-meni-pause and the changes your body goes thru including the dreaded Meni-pot! (new fat on your stomach you NEVER had before) I found articles on a high grade - I won't mention it because I am not 'promoting' anything - I have lost the extra abdominal fat, honestly haven't felt better in long time.. was it the supplement? I don't know for sure.. I think this article is really interesting- I think like THIS and any supplement that isn't pharmaceutical grade and not adhering to the 'good manufacturing' guidelines is the question of quality. The first comment made could be someone that took a 5 dollar bottle of crap claiming to be the product with low to no levels of it in there.. http://www.natural-progesterone-advisory-network.com/the-cruciferous-choice-diindolylmethane-or-i3c/ Do your research and I would highly recommend you give it a try.