Blog

show/hide this revision's text 2 added 155 characters in body

Aspirin is useful only as acute remedy. Chronic use is dangerous, and acute use is dangerous in kids and babies.

Chronic use in adults will produce stomach bleeding for sure and deplete your vitamin C

Its better to just use fish oil. If you have to take it, use vitamin C during the day to prevent bleeding.

Vitamin C has been shown to reduce gastric mucosal damage and gastric toxicity induced by ASA-generated reactive oxygen metabolites [55, 56]. After ingestion, both aspirin and salsalate are rapidly converted ro salicylic acid. Aspirin and salicylic acid can increase urinary excretion of vitamin C, lower leukocyte ascorbic acid levels (by 50%), and decrease its metabolic availability [57 - 60]. The gastric mucosa is the largest depot of ascorbic acid in human body, with ascorbic acid concentrations 25 times higher than in plasma [61]. Some data suggest that aspirin may protect endothelial cells from oxidant damage via the nitric oxide (NO) cyclic guanosine monophosphate (cGMP) path way [62,63]. However, gastric epithelial cells require vitamin C to translate inducible heme oxygenase (HO-1) miRNA "into active protein, which then may exert gastroprotection by its antioxidant and vasodilative propertie... Induction of HO-1 is considered to be an adaptive cellular mechanism in response to oxidative stress" [64]. Thus, a significant body of data shows that the oxidative damage caused by aspirin can induce exfoliation of gastric epithelial cells, formation of gastric erosions, and GI hemorrhage. In particular, the gastric mucosa of individuals deficient in vitamin C (and possibly other, synergistic nutrients) might be less able to increase the rate of cell production and therefore susceptible to increased bleeding after aspirin ingestion. Vitamins A, E, and C and bioflavonoids may enhance the "antiaggregative effect of aspirin, prolongate its activity, [and] increase hypocoaguloemia due to reduced releasing of thrombocyte factors 3 and 4 into plasma

show/hide this revision's text 1

Aspirin is useful only as acute remedy. Chronic use is dangerous, and acute use is dangerous in kids and babies.

Chronic use in adults will produce stomach bleeding for sure and deplete your vitamin C

Its better to just use fish oil. If you have to take it, use vitamin C during the day to prevent bleeding.

Vitamin C has been shown to reduce gastric mucosal damage and gastric toxicity induced by ASA-generated reactive oxygen metabolites [55, 56]. After ingestion, both aspirin and salsalate are rapidly converted ro salicylic acid. Aspirin and salicylic acid can increase urinary excretion of vitamin C, lower leukocyte ascorbic acid levels (by 50%), and decrease its metabolic availability [57 - 60]. The gastric mucosa is the largest depot of ascorbic acid in human body, with ascorbic acid concentrations 25 times higher than in plasma [61]. Some data suggest that aspirin may protect endothelial cells from oxidant damage via the nitric oxide (NO) cyclic guanosine monophosphate (cGMP) path way [62,63]. However, gastric epithelial cells require vitamin C to translate inducible heme oxygenase (HO-1) miRNA "into active protein, which then may exert gastroprotection by its antioxidant and vasodilative propertie... Induction of HO-1 is considered to be an adaptive cellular mechanism in response to oxidative stress" [64]. Thus, a significant body of data shows that the oxidative damage caused by aspirin can induce exfoliation of gastric epithelial cells, formation of gastric erosions, and GI hemorrhage. In particular, the gastric mucosa of individuals deficient in vitamin C (and possibly other, synergistic nutrients) might be less able to increase the rate of cell production and therefore susceptible to increased bleeding after aspirin ingestion. Vitamins A, E, and C and bioflavonoids may enhance the "antiaggregative effect of aspirin, prolongate its activity, [and] increase hypocoaguloemia due to reduced releasing of thrombocyte factors 3 and 4 into plasma