I wouldn’t cut it back to near zero because I know that doesn’t work for me, but the thing is it is pretty silly to go from “reduced insulin in worms” to “near zero carbohydrates in humans”. It is always kind of funny to see one simple mechanism (insulin-sensitive gene in worms) translated to a new lifestyle for humans (near zero carb diet).

Insulin and carbs are not synonymous, and insulin has more than one function and is part of a huge symphony of biochemical activity that goes on in the human body - a symphony that we likely are missing a lot of understanding. Leptin was just discovered a short time ago. What else is going on that we have no knowledge of. Somebody thought anabolic steroids were a really good idea at one point.

I also believe the longevity studies in mice based upon reduced calories showed that there was very little benefit to longevity if the protocol was started as an adult.

I wouldn’t cut it back to zero because I know that doesn’t work for me, but the thing is it is pretty silly to go from “reduced insulin in worms” to “zero carbohydrates in humans”. It is always kind of funny to see one simple mechanism (insulin-sensitive gene in worms) translated to a new lifestyle for humans (zero carb diet).

Insulin and carbs are not synonymous, and insulin has more than one function and is part of a huge symphony of biochemical activity that goes on in the human body - a symphony that we likely are missing a lot of understanding. Leptin was just discovered a short time ago. What else is going on that we have no knowledge of. Somebody thought anabolic steroids were a really good idea at one point.

I also believe the longevity studies in mice based upon reduced calories showed that there was very little benefit to longevity if the protocol was started as an adult.