For me, yes! When I went VLC for several months, an old friend visited me and stayed on my couch. We hadn't seen each other for quite a while, not since I'd changed my eating. Our whole interaction was off, none of the usual funny banter we have. My end of the conversation was detached, literal. I went to bed promptly at 9 pm every night, even if she wanted to stay up. It was weird, like I was some alien from an ice planet running a hotel.
We were walking by the ocean and I got a cold-brew coffee. I started drinking it and my eyes lit up, exclaiming it was the best coffee I'd ever had. About halfway into the cup, I realized it's sugar,. There was sugar in the coffee, the first I had tasted in maybe 6 months. I suddenly felt my emotions coming back to me. I was warm, laughing, empathetic, silly, my whole personality changed. "I was wondering what the hell was wrong with you!"
I prefer the more stable emotional spectrum I seem to dwell in when I eat moderate carb paleo (VLC wasn't for me, for the reason above and others), but sugar is certainly drug-like. It's not sustainable for me. Like a lot of people here, sugar causes more cravings, then I'm just on the roller coaster. Since I was more-or-less chasing a sugar high for years without realizing it, the attendant moods are what I constructed as "my personality," so even if I prefer my disposition while eating paleo, it be kind of jarring to lose that.