Sulfur supplementation for Glutathione production?

by (2198) Updated July 11, 2013 at 5:53 PM Created July 19, 2012 at 3:04 AM

Glutathione is known as the mother of all antioxidants and a super liver detoxifier.

In addition to folate and vitamin b6 and b12 sulfur is an important precursor.

You can supplement folate (especially as 5-methyl-folate NOT folic acid), b6 and b12 but what about sulfur? Many people do not eat nearly enough cruciferous vegetables that provide the highest amount of sulfur. Can you safely/effectively supplement sulfur? Have you done it?

I have never seen a sulfur supplement in capsules. Only in powdered form I would imagine it is pretty stinky.

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12 Replies

134 · July 19, 2012 at 3:33 AM

N Acetyle Cystine, or NAC is a great way to supplement for Glutathione production. I take it twice a day. Other than that, my sister get injections of Glutatione that she swears by, if you can find a doctor that will prescribe it. Some links on NAC:



40652 · July 19, 2012 at 11:59 AM

To figure out what to supplement to get enhanced glutathione production, you need to know what glutathione consists of and how it's biosynthesized. Glutathione is a tripeptide of glutamic acid, cysteine and glycine. It's not your typical peptide linkage as the glutamic acid is linked through its side chain. As others have pointed out, cysteine is the limiting point in glutathione production, meaning that's what you'll need to target for supplementation. Glycine and glutamate are common amino-acids, both non-essential.

Cysteine is non-essential, is made from the amino acid methionine, another sulfur containing amino acid. Methionine is essential, meaning we cannot biosynthesize it and it must be obtained via diet.

So any supplementation/feeding strategy to enhance endogenous glutathione production should target increased cysteine and methionine production. Inorganic sulfur (sulfides, sulfites, sulfates, etc...) cannot be used in humans (plants do).

In other words: eat meat.

38 · July 19, 2012 at 4:59 AM

The three amino acids necessary for glutathione production are cysteine, glutamic acid and glycine...with cysteine being the rate limiting factor for intracellular glutathione synthesis (because it is rare in our food).

A whey protein concentrate is an excellent source of cysteine, and actually contains more than you will find in any other food. I would stick with consuming foods that actually contain the precursers necessary for GSH production before I would look into increasing my sulfur intake.

Here's some more info about whey protein and glutathione if you're interested:)


Good luck!

24412 · July 19, 2012 at 7:16 AM

Sorry to answer your question with a question, I'm too tired to research this right now, but isn't Epsom Salt magnesium sulfate? If the magnesium can be absorbed transdermally, wouldn't the sulphate also be taken up and act as supplemental sulfur?

4395 · July 19, 2012 at 5:31 AM

I just happened to see this article today on the Weston A. Price Foundation website.
It may be useful to you.

Sulfur Deficiency
Written by Stephanie Seneff, PhD
July 2 2011


Edited for spelling

935 · July 19, 2012 at 4:11 AM

MSM Milk Thistle Vitamin C and E (indirectly) Selenium (indirectly) Eggs are also rich in sulfur

0 · July 11, 2013 at 5:53 PM

I hit this paleohack site googling sulfur and glutathione to try to learn how these to substances work together in the body.

In any case anyone following this thread might be interested in organic sulfur. Which is really just high quality MSM. Seems even if you do eat vegetables that are known to have sulfur in them, the regular run of the mill farming has just about removed sulfur from the food chain/cycle. Sulfur deficiency could be the issue to many health issues. (?)


3967 · January 05, 2013 at 4:32 AM

Do Epsom salts (magnesium sulfate) provide sufficient sulphur?

0 · July 19, 2012 at 3:39 PM

Protandim, a patented herbal supplement, increases glutathione production by 300%: http://bit.ly/LA7pB0

-4 · January 16, 2013 at 6:03 PM

The best way to increase your glutathione levels is with Dr Robert Kellers supplement His partners formed RobKeller MD recently and the product is only $39.95 for 180 capsules

I am a direct affiliate with the company.

go to [sales link removed]

and check it out. Your body will thank you!!

-4 · January 16, 2013 at 5:44 PM

The best way to increase your glutathione levels is with Dr Robert Kellers supplement His partners formed RobKeller MD recently and the product is only $39.95 for 180 capsules

I am a direct affiliate with the company.

go to [link removed]

and check it out. Your body will thank you!!

-2 · January 05, 2013 at 1:11 AM

we do not get enough sulfur from our diet,in most cases. actually the sulfur you get in powder form does not taste bad at all.i took sulfur when i was young and came to this site wondering if i should resume taking it.i haven'tyet found the answer.i know you get it from the cruciferous vegetables,such as:kale,cabbage,cauliflower,brocoli,radishes and etc.onions and garlic also are sources of sulfur. so,would you recommend supplementing with it or not ?

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