Supplements for Insulin Resistance

by (15) Updated October 23, 2011 at 12:20 PM Created October 23, 2011 at 4:20 AM

I've read about CLA and ALA (alpha lipoic acid) to help treat insulin resistance. Anyone have any experience with or knowledge of these supplements? I know diet and exercise are huge factors in increasing insulin sensitivity but I was wondering if there were any supplements I could take to aid the process?

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5 Replies

25197 · October 23, 2011 at 4:36 AM

CLA is worthless as a supplement. You need to get it from food because most supplements have omega 6 oils as a source of the CLA. You need higher oral and topic sources of Magnesium. You need a lot of things to optimize mitochondrial functioning. IR basically makes your mitochondria inefficient. There is a ton to do.

Here is a pretty complete list I use for diabetic peripheral neuropathy.


3652 · October 23, 2011 at 12:20 PM


I concur with all the above. Great items! Exercise works synergistically (both cardio 60% of max, lifting and HIIT) with food/targeted nutraceuticals which lower inflammation. Stopping IR inducers are important (mental stress, sleep deprivation, physical stressors, and drugs (synthetic hormones, cortisone, certain BP drugs) and correcting deficiencies (healthy gut, omega-3, GLA melatonin, vitamin D/sunlight, testosterone, progesterone, etc). Also heavy metals cause IR; see handout.

From the handout above:

Intracellular glutathione is an important antioxidant. It can be increased by these foods (Houston, 2005; p. 300):

• Whey protein

• Cruciferous vegetables

• Green tea

• Onions and garlic can reduce glucose and increase free insulin (Houston, 2005; p. 302).

• Bitter melon reduces glucose and HbA1C (Houston, 2005; p. 302).

• Cinnamon, used liberally (up to 6 gm/day) can improve blood sugar and most parameters of CVD (Houston, 2005; p. 306).

EGCG (green tea extract) 500 mg 2 times daily

Gymnema sylvestre 400 mg of extract, divided doses

Ginseng 200–300 mg 2 times daily

Alpha lipoic acid (or 100–1800 mg R-lipoic acid) best with:

Chromium (GTF) 8 mcg/kg/day = 3.6 mg/lb

Vanadate Dose to 40–80 mcg/L in serum

Magnesium, with: 500 mg 2 times daily

Vitamin B6 50–100 mg

Niacin (inositol hexani- 25 mg/kg. = 11.5 mg/lb cotinate is best)

Biotin 8–16 mg

Vitamin E (mixed toco- 200–400 IU pherols and tocotrienols)

Vitamin D3 1200–2000 IU [personally I target serum 70 ng/ml] (Houston, 2005; p. 81)

Potassium 500 mg

Zinc 30–50 mg

Fish oil DHA-600 mg./EPA-900 mg

Selenium 200 mcg

Manganese 5–10 mg

GLA (gamma linolenic 500 mg 2 times daily acid)

CLA (conjugated no established dose linoleic acid) [I'd concur w/Quilt -- supplement here is synthetic and inferior]

L-carnitine 2 gm 2 times daily

Taurine 1.5–3 gm 2 times daily

N-acetylcysteine 1000 mg. 2 times daily

Pycnogenol 100–200 mg [this is $$$ but worth it as it detoxes gently heavy metals and great studies in a variety of different health conditions including improving even erectile dysfunction rapidly]

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39204 · October 23, 2011 at 4:25 AM

Chromium (50mcg), magnesium (400mg) and manganese (10mg).

77338 · October 23, 2011 at 8:25 AM

EPA (fish oil), Vitamin C, Vitamin D, Mg, White tea, Cinnamon, Policosanol

47 · October 23, 2011 at 6:45 AM

Drink some green tea in the afternoon. You'll find that green tea works better than ALA or Chromium combined in dopping blood sugar. I never saw much hypoglycemic effect from ALA nor Chromium, supposedly insulin mimetics. The effect is huge from the tea.

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