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What's the deal with PQQ?

by (20411)
Updated 17 minutes ago
Created September 27, 2011 at 2:08 PM

PQQ is pyrroloquinoline quinone, a vitamin discovered in 1979 - anyone taking it as a supplement? It appears to increase biogenesis of mitochondria, which could be a good thing for people that have damaged mitochondria.

Doesn't seem to be a hot topic here, but it's mentioned in a few comments. Now Dr. K says it's a key supplement that he recommends:

http://jackkruse.com/what-are-the-top-ten-paleo-supplements/

Why am I only hearing about this now? Is it important? Can I get enough of this stuff from real food?

Some more background:

http://www.ncbi.nlm.nih.gov/pubmed/21814553

Edit:

A better paper on PQQ and biogenesis of mitochondria:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804159/?tool=pubmed

Here's a ref on PQQ in food:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1136652/pdf/biochemj00065-0028.pdf

Natto, green tea, parsley, green pepper, kiwi and papaya are good sources - although the paper only tested 26 foods commonly available in Japan.

Peter's post on impaired mitochondria/fat oxidation leading to obesity:

http://high-fat-nutrition.blogspot.com/2011/09/did-you-over-eat-yourself-in-to-obesity.html

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 28, 2011 at 1:09 AM

One month wont reverse yrs of damage. Sustain the assault of glycation to win

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 28, 2011 at 1:09 AM

Peter is spot on based upon my clinical exprience

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 28, 2011 at 1:05 AM

There is no good tx for neuropathy so you need to go try to reestablish the power supply big time in neurons

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 28, 2011 at 1:04 AM

Ten mgs for neuropathy is way too low!

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11254 · September 27, 2011 at 9:14 PM

Yes. Real foods are what I prefer, but pain tends to get me thinking in a medical way, even though it is doubtful that a three month supplementation plan would get me pain free.

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20411 · September 27, 2011 at 6:22 PM

Maybe using real foods would work as well - green tea, parsley, green pepper, etc.

A968087cc1dd66d480749c02e4619ef4
20411 · September 27, 2011 at 4:00 PM

I don't usually read the papers that Peter links to, but this time I did and it was fascinating! Full free text is here: http://brn.sagepub.com/content/10/4/356.long

A968087cc1dd66d480749c02e4619ef4
20411 · September 27, 2011 at 3:54 PM

Yeah, I read Peter's post and later Dr. K's blog entry on PQQ. I kinda tied the two together as well. Of course, "forced weight loss" does not imply food quality, so perhaps there is hope!

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2 Answers

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11254 · September 27, 2011 at 5:40 PM

I supplemented with it for about two months at 10mg because I was trying to follow Dr. Kruse's recommendations about neuropathy- I was hoping it would help with whatever was going on with the nerves in my face. Anyway, I took it with all the other supplements he recommends, and together they are all pretty expensive. PQQ seemed to help some, but after the second month I simply didn't think whatever benefits I was getting was worth the cost. I also read, I believe on the life extension forums, that PQQ increases the mitochondria, but as soon as you stop supplementing, the mitochondria plummet again.

So right now, if I had the money, I'd probably start another round of supplementing for mitochondria again, because it did help some , plus I'd do some serious sprinting and weights. What I'd like is a clear protocol to permanently increased levels of mitochondria- and it seems, long term, this is what exercise is for. Mitochondria plummets in athletes who retire from sports. The supplementation probably just helps us get to a higher level faster, but to keep that level, we need to use them.

Three months of supplementation maybe? And frankly, at higher levels than I supplemented intially. I think for PQQ it 20mg was the supposed effective dose. Add in all the other supplements and you are looking at an expensive experiment, but it's probably justifiable if it can be a short duration of supplementation rather than yet another overpriced thing we all just need to take forever.

7bf306ada57db47547e9da39a415edf6
11254 · September 27, 2011 at 9:14 PM

Yes. Real foods are what I prefer, but pain tends to get me thinking in a medical way, even though it is doubtful that a three month supplementation plan would get me pain free.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 28, 2011 at 1:09 AM

One month wont reverse yrs of damage. Sustain the assault of glycation to win

A968087cc1dd66d480749c02e4619ef4
20411 · September 27, 2011 at 6:22 PM

Maybe using real foods would work as well - green tea, parsley, green pepper, etc.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 28, 2011 at 1:04 AM

Ten mgs for neuropathy is way too low!

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 28, 2011 at 1:05 AM

There is no good tx for neuropathy so you need to go try to reestablish the power supply big time in neurons

D5096ff5baffc0ba5d20b21346414a7a
1
1112 · September 27, 2011 at 3:47 PM

I had just read the following from Peter on Hyperlipid before I saw this question. Can someone answer and explain the connection. Do those of us who have messed up mitochondria need to take PQQ forever or can we regain healthy mitochondria?

"If you have duff mitochondria you accumulate fatty acid derivatives in your cytoplasm. They cause insulin resistance. Once you have insulin resistance you will be chronically hyperinsulinaemic and, in all probability, go on to develop obesity as a direct consequence of that hyperinsulinaemia. Let's make this plain. Mitochondrial dysfunction is present before obesity develops and does not revert to normal on forced weight loss."

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 28, 2011 at 1:09 AM

Peter is spot on based upon my clinical exprience

A968087cc1dd66d480749c02e4619ef4
20411 · September 27, 2011 at 3:54 PM

Yeah, I read Peter's post and later Dr. K's blog entry on PQQ. I kinda tied the two together as well. Of course, "forced weight loss" does not imply food quality, so perhaps there is hope!

A968087cc1dd66d480749c02e4619ef4
20411 · September 27, 2011 at 4:00 PM

I don't usually read the papers that Peter links to, but this time I did and it was fascinating! Full free text is here: http://brn.sagepub.com/content/10/4/356.long

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