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Any benefit to supplementing with Vit K2 in the MK-7 form?

by (2065)
Updated September 16, 2014 at 7:32 PM
Created October 22, 2011 at 4:20 PM

I accidentally bought a k2 supplement in the MK-7 form instead of MK-4. Would you bother taking this? Thanks a lot!

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 07, 2013 at 1:28 AM

Jay K3 is being studied in several oncologic trials as we speak. It is being used by humans just not wide scaled because we are studying it.

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 24, 2011 at 6:31 PM

You BOTH wrote it is used for cancer PREVENTION. That is DIFFERENT from cancer TREATMENT. Use of vitamin K3 in healthy people to prevent cancer is untested and unwise.

85026a0abe715229761956fbbee1cba0
78417 · October 23, 2011 at 3:37 PM

Yes, its chemo, when did I say it isn't ? Anyway, the fact that K3 has anticancer role probably translates to other K vitamins in some level. K3 is provitamin K2, so at least part of it is used to make it in the body. K3 is used extensively with animals.

85026a0abe715229761956fbbee1cba0
78417 · October 23, 2011 at 3:26 PM

Yes, MK-7 is found A LOT in the fermented diet of any kind. Its even produced by microbiota, if you have them :)

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 23, 2011 at 2:30 AM

Not all true. Mk-7 is in our diets in cheese. Also, there's no evidence that complexes are better.

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 23, 2011 at 1:02 AM

Maj, similar comment for you. IV vit C and K3 are used because they are OXIDANTS, meaning they kill shit, like cancer cells. It's chemo.

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 23, 2011 at 1:00 AM

QUILT, that's plum wrong. K3, or menadione, is a synthetic analogue of vitamin K. As far as I know it's rarely used in humans (I think it's just used to treat, but not prevent, some cancers). It is used in some commercial animal feeds. Not stuff i would mess around with

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 23, 2011 at 12:59 AM

QUILT, that's plum wrong. K3, or menadione, is a synthetic analogue of vitamin K. As far as I know it's rarely used in humans (rally just for chemotherapy (i.e., to kill cancer cells not to prevent their formation). It is used in some commercial animal feeds. Not stuff i would mess around with.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · October 22, 2011 at 9:00 PM

K3 is the cancer preventer in the k vitamins. K2 plays a role too. Plus one

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · October 22, 2011 at 8:59 PM

Plus one.......all true

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · October 22, 2011 at 8:59 PM

Has a long half life .....than mk 4. For boenes and heart i love mk 4

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:33 PM

See some info here: http://www.naturemedclinic.com/intravenous-vitamin-c.php

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:31 PM

It looks like K is very important for cancer prevention. Apatone, combination of synthetic K3 and vitamin C megadose looks promicing for prostate cancer and Riordan clinic is using the same protocol for all cancers with big success.

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:08 PM

Here is from book: http://books.google.com/books?id=-xn_5iXneu0C&lpg=PA11&ots=hB7wrYz9NJ&dq=menaquinone-7%20benefits&pg=PA11#v=onepage&q=menaquinone-7%20benefits&f=false

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:04 PM

http://www.clotinase.com/research/Effect-of-vitamin-K2-(menaquinone-7)-in-fermented-soybean.pdf http://www.nextbio.com/b/search/individualtrial.nb?id=NCT00732576

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:03 PM

Ongoing: http://clinicaltrials.gov/ct2/show/NCT00642551 Just search god damn it.

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:03 PM

Or: http://www.ncbi.nlm.nih.gov/pubmed/15630245

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 6:54 PM

Not true. For instance: http://www.ncbi.nlm.nih.gov/pubmed/17158229. MK-7 is also produced by bacteria and part of beneficial effects of those microbiota must be due to it.

E5c7f14800c5992831f5c70fa746dc5c
12847 · October 22, 2011 at 6:34 PM

mk-4 is the only one with proven benefits in clinical trials

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3 Answers

4781cf8ae1bfcb558dfb056af17bea94
5
4359 · October 22, 2011 at 7:25 PM

There's decent data for K1, and multiple forms of K2, including mk-7 and mk-4. The type of data supporting each is currently different, a testament to the infancy of the state of knowledge on this topic.

There's a randomized placebo controlled trial in humans showing, as a secondary endpoint, drastic reductions of cancer among otherwise D3 replete women (mean serum level 30ng/ml) who took 5mg of k1 (a big dose). There's also generally good safety date for k1.

K2 in the mk-7 form has good epidemiological data, though I suspect some of the benefits that K2 shows in these studies is really due to the benefits of eating dairy fat (but the researchers can't accept that so they attribute it to K2). Same phenomenon for CLA.

Mk-4 has decent animal data behind it and some short-term trials in people (but only at massive doses that, in my opinion, would be quite unwise to take for purposes of disease prevention).

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · September 07, 2013 at 1:28 AM

Jay K3 is being studied in several oncologic trials as we speak. It is being used by humans just not wide scaled because we are studying it.

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 24, 2011 at 6:31 PM

You BOTH wrote it is used for cancer PREVENTION. That is DIFFERENT from cancer TREATMENT. Use of vitamin K3 in healthy people to prevent cancer is untested and unwise.

85026a0abe715229761956fbbee1cba0
78417 · October 23, 2011 at 3:37 PM

Yes, its chemo, when did I say it isn't ? Anyway, the fact that K3 has anticancer role probably translates to other K vitamins in some level. K3 is provitamin K2, so at least part of it is used to make it in the body. K3 is used extensively with animals.

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 23, 2011 at 1:02 AM

Maj, similar comment for you. IV vit C and K3 are used because they are OXIDANTS, meaning they kill shit, like cancer cells. It's chemo.

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 23, 2011 at 1:00 AM

QUILT, that's plum wrong. K3, or menadione, is a synthetic analogue of vitamin K. As far as I know it's rarely used in humans (I think it's just used to treat, but not prevent, some cancers). It is used in some commercial animal feeds. Not stuff i would mess around with

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 23, 2011 at 12:59 AM

QUILT, that's plum wrong. K3, or menadione, is a synthetic analogue of vitamin K. As far as I know it's rarely used in humans (rally just for chemotherapy (i.e., to kill cancer cells not to prevent their formation). It is used in some commercial animal feeds. Not stuff i would mess around with.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · October 22, 2011 at 9:00 PM

K3 is the cancer preventer in the k vitamins. K2 plays a role too. Plus one

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:33 PM

See some info here: http://www.naturemedclinic.com/intravenous-vitamin-c.php

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:31 PM

It looks like K is very important for cancer prevention. Apatone, combination of synthetic K3 and vitamin C megadose looks promicing for prostate cancer and Riordan clinic is using the same protocol for all cancers with big success.

85026a0abe715229761956fbbee1cba0
5
78417 · October 22, 2011 at 5:41 PM

Yes, it might even be the most powerful form. MK-7 is found in fermented foods and that is basically the one your bacteria make in intestines.

MK-7 has a profound ability at preventing osteoporosis, and even at reversing it and calcification. It is the main stuff in natto and also one of dominant forms in human serum.

Ideally you should aim for mix of all K vitamins. Fermented foods contain other MK forms (8,3, 9 etc..) with possible different roles in the body.

It looks like its very safe. This is interesting

Therefore, under the conditions of this experiment, the median lethal dose (LD50) of MK-7 after a single oral administration in mice was determined to be greater than the limit dose level of 2000???mg/kg body weight. The no observed adverse effect level (NOAEL) of MK-7, when administered orally to rats for 90 days, was considered to be equal to 10???mg/kg body weight/day, the highest dose tested, based on lack of toxicity during the 90-day study period

Read More: http://informahealthcare.com/doi/abs/10.3109/15376516.2011.568983

This striking lack of toxicities with orthomolecular compunds relative to pharmaceuticlas is the reason why Pauling created new medicine. Ofcourse, rat observations do not necessarily translate to humans, but since you can't test LD-50 on humans its reasonable alternative.

See this table for dietary reference.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · October 22, 2011 at 8:59 PM

Has a long half life .....than mk 4. For boenes and heart i love mk 4

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:08 PM

Here is from book: http://books.google.com/books?id=-xn_5iXneu0C&lpg=PA11&ots=hB7wrYz9NJ&dq=menaquinone-7%20benefits&pg=PA11#v=onepage&q=menaquinone-7%20benefits&f=false

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:04 PM

http://www.clotinase.com/research/Effect-of-vitamin-K2-(menaquinone-7)-in-fermented-soybean.pdf http://www.nextbio.com/b/search/individualtrial.nb?id=NCT00732576

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:03 PM

Ongoing: http://clinicaltrials.gov/ct2/show/NCT00642551 Just search god damn it.

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 7:03 PM

Or: http://www.ncbi.nlm.nih.gov/pubmed/15630245

85026a0abe715229761956fbbee1cba0
78417 · October 22, 2011 at 6:54 PM

Not true. For instance: http://www.ncbi.nlm.nih.gov/pubmed/17158229. MK-7 is also produced by bacteria and part of beneficial effects of those microbiota must be due to it.

E5c7f14800c5992831f5c70fa746dc5c
12847 · October 22, 2011 at 6:34 PM

mk-4 is the only one with proven benefits in clinical trials

5e36f73c3f95eb4ea13a009f4936449f
4
8255 · October 22, 2011 at 6:28 PM

My recollection is that the MK-4 K2 variant is fast acting and cleared from the system quickly, and MK-7 lasts longer in the blood. So it's definitely worth taking it if you've got it, although complex's of the K vitamins are better. The various K vitamins help out with osteoporosis, arterial calcification, cancers, etc. and the K2-MK7 variant is not really in our diets (unless you eat Natto a lot, not common in the US diet)

85026a0abe715229761956fbbee1cba0
78417 · October 23, 2011 at 3:26 PM

Yes, MK-7 is found A LOT in the fermented diet of any kind. Its even produced by microbiota, if you have them :)

4781cf8ae1bfcb558dfb056af17bea94
4359 · October 23, 2011 at 2:30 AM

Not all true. Mk-7 is in our diets in cheese. Also, there's no evidence that complexes are better.

Ed71ab1c75c6a9bd217a599db0a3e117
25467 · October 22, 2011 at 8:59 PM

Plus one.......all true

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