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Why has Vitamin K2 supplementation stopped working for me?

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Updated about 8 hours ago
Created March 21, 2014 at 5:06 PM

Hello,

I've been taking Carlson Vitamin K2 (menatetrenone - the mk-4 version of k2) for almost a year now. I started at 5mg every other day to every few days. Taking it sporadically like that made my teeth extremely smooth, got rid of excess plaque, and cleared up some ear issues.

I noticed a few months ago that I stopped seeing results so I tried switching to taking it every day at 5mg a day and then even tried taking it every day at 10mg a day. Still no results.

Any ideas on why I would stop seeing results on mk-4? The only thing that really changed the past couple months was me buckling down and taking my vitamin D every day. I tried stopping that to see if it would allow the mk-4 to start working again, but it hasn't.

Thank You.

32f5749fa6cf7adbeb0b0b031ba82b46
41560 · March 22, 2014 at 5:00 PM

Fat-soluble molecules bind to serum albumin to get around… longer chain (MK-7) molecules bind stronger than shorter chain (MK-4) because MK-4 has a lower log-P than MK-7. Still not convinced serum concentrations don't mean much as MK-4 could be "cleared" simply by leaving serum and going where it is needed.

Cb9a270955e2c277a02c4a4b5dad10b5
10994 · March 22, 2014 at 3:30 PM

Hmm, I agree that mk-4 is the type actually made by our bodies. Would be interesting to see if mk4 and mk7 bind to the same receptors. I'm not finding a published study specifically testing only for the half life of mk4/mk7 in serum. Here are two links though. One is an unpublished study produced by a manufacturer of k2 and one is a published study in Osteoperosis int. that briefly mentions the fact that mk7 lasts longer in serum than mk4. 1) http://www.menaq7.com/?page=absorption 2) http://www.ncbi.nlm.nih.gov/pubmed/23525894 .

32f5749fa6cf7adbeb0b0b031ba82b46
41560 · March 22, 2014 at 3:07 PM

Except MK-4 is the variety of vitamin K2 our bodies naturally make.

Everybody is claiming the half-life of MK-4 is so low, except they read a Mercola nonsense article. Data please.

Cbad09eef2dc0bf4b5f174b8e0c99100
0 · March 22, 2014 at 2:48 PM

Thats interesting. How do you mean it has stopped working. Are you getting sensitive teeth even while taking it.

Are you taking it with fatty food, how much vitamin d are you taking?

Cb9a270955e2c277a02c4a4b5dad10b5
10994 · March 22, 2014 at 11:50 AM

This is a good point, mk7's half life is 3 days vs a few hours for mk4.

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529 · March 22, 2014 at 11:29 AM

In addition, the mk4 in supplements is synthetic, whereas mk7 is usually derived from natto.

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Cb9a270955e2c277a02c4a4b5dad10b5
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10994 · March 21, 2014 at 5:22 PM

Vitamin D creates these little uncarboxylated proteins that Vitamin K then activates. If you're creating more of these undercarboxylated proteins than you can carboxylate by taking supplementary vitamin D then this would be a plausible cause for the undoing of whatever positive effects you had previously noticed from taking the k2-mk4 alone.

Try stopping the Vitamin d for a month and see if the results come back. You need to stop it for more than a few days to bring your vitamin d levels back down. Alternatively you could try taking more vitamin k, but that stuff is expensive so that wouldn't be my first choice.

5ae3774df8015b4d7801f6642bc89f97
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0 · March 22, 2014 at 5:34 AM

Like the other person who responded said, when D is increased, so is the need for K. Try taking K2-mk7. It has a much longer half life than the mk4 version.

Cb9a270955e2c277a02c4a4b5dad10b5
10994 · March 22, 2014 at 11:50 AM

This is a good point, mk7's half life is 3 days vs a few hours for mk4.

32f5749fa6cf7adbeb0b0b031ba82b46
41560 · March 22, 2014 at 3:07 PM

Except MK-4 is the variety of vitamin K2 our bodies naturally make.

Everybody is claiming the half-life of MK-4 is so low, except they read a Mercola nonsense article. Data please.

Be803dcde63e3cf5e21cc121097b8158
529 · March 22, 2014 at 11:29 AM

In addition, the mk4 in supplements is synthetic, whereas mk7 is usually derived from natto.

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