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Spironolactone, DHEA, Testosterone etcc..

by (871)
Updated about 3 hours ago
Created February 02, 2013 at 7:36 PM

Hello All,

Question regarding Spironolactone (aldactone) I have been on this for my skin for quite a long time and it was recently brought to my attention that it is one of the reasons I am not seeing results from my training, as it is suppressing my natural testosterone. So I am lowering my dose and seeing what happens.

Of course, I know there will be acne breakouts, but I am wondering if someone could help clarify the different ways in which DHEA and testosterone flow and work with regards to pathways. And if there is just an increase in Free Test. that will allow me to build muscle and lean out.

If anyone has had an experience with this, do share!

INFO: 28yrs,Female,history of PCOS,on 100mg of Spirono. 1000mg of Metformin and Bio-iden. Progesterone.

Goal is to get my hormones balanced naturally!

Thanks!

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17103 · August 23, 2013 at 3:35 PM

I don't know about this particular substance, but most things you put on your skin are absorbed to some degree. That's why nicotine, dramamine, testosterone, etc. patches/creams work - as a rule - in terms of hygiene products, if you wouldn't want to eat it, don't put it on your skin. Also, some things that would be damaged by digestion can be absorbed through skin. For most, if you cut open a clove of garlic and rub it on your palm, you can detect a garlic odor on your breath in less than 30mins.

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17103 · April 15, 2013 at 10:17 AM

The only problem is exactly that, it will convert it to what it thinks it needs. If you have a lot of chronic stress, that DHEA will get converted to adrenaline - or if you do make testosterone and you have lots of fat, it will aromatize to a form of estrogen. Sometimes, you want it to do the opposite.

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5 Answers

40599fad2a8618c6a54d24da5777fe3e
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0 · May 03, 2013 at 8:49 AM

"Even applied topically it effects the entire body."

Can you show me a study that prove that ?

It do not effect the whole body if applied topical.

http://www.ncbi.nlm.nih.gov/pubmed/3411088

96440612cf0fcf366bf5ad8f776fca84
17103 · August 23, 2013 at 3:35 PM

I don't know about this particular substance, but most things you put on your skin are absorbed to some degree. That's why nicotine, dramamine, testosterone, etc. patches/creams work - as a rule - in terms of hygiene products, if you wouldn't want to eat it, don't put it on your skin. Also, some things that would be damaged by digestion can be absorbed through skin. For most, if you cut open a clove of garlic and rub it on your palm, you can detect a garlic odor on your breath in less than 30mins.

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800 · April 14, 2013 at 10:43 PM

"Spironolactone is a potent antagonist of the androgen receptor as well as an inhibitor of androgen production" http://en.wikipedia.org/wiki/Spironolactone

Even applied topically it effects the entire body. If your androgen receptor count is reduced, or the activity of your androgen receptors is reduced, your body will naturally downregulate its own testosterone production as a result.

I had light facial acne for many years, it went away after dropping gluten for several months.

Hope this helps

kaz

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3432 · March 31, 2013 at 3:34 PM

Have you seen an allergist for your skin troubles? Somewhere around 9/10 skin disorders are reactions to the diet or environment. Wait around for a dermatologist to clue you to that one...

Do not attempt to regulate hormones (especially reproductive hormones and/or precursors) without specific empirical awareness of what your body is doing. Over-treating can lead to permanent changes in your body.

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190 · February 02, 2013 at 11:34 PM

How do you know there will be acne break outs if you've never been off it? I mean, just thinking here, but maybe since the time you have been on it your skin has cleared up naturally? Just a thought.

Anyways, I'd just ditch the stuff that you don't absolutely need to be healthy. Sure it will take some time for your hormones to balance out naturally, and at first you might feel worse, but no pain, no gain, you know?

I know there are people who take steroids to achieve a certain goal and then have to come off them for a certain time to establish hormonal balance again. It's called cycling. In the meantime they typically take herbs to help jump start the re-balancing.

Not telling you what to do because I have no experience, but just that if it were me I'd probably just stop all the meds and try to achieve hormonal balance through diet, proper exercise, yoga/stress reduction and other stuff like that.

Good luck~!

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38 · February 17, 2013 at 2:43 AM

DHEA is a precursor hormone made by the adrenal glands. The body can change it into any sex hormone it needs. If you need estrogen, your body will turn it into estrogen. If you need testosterone, your body will turn it into testosterone. Taking DHEA will not guarantee that your body will change it into the sex hormone you desire.

I take DHEA because I don't have any adrenal glands. People under the age of 40 aren't advised to take it without a doctor's supervision. There are some studies linking its use with hormonal cancers. If you decide to take it, it would probably be best to disuss it with a doctor.

96440612cf0fcf366bf5ad8f776fca84
17103 · April 15, 2013 at 10:17 AM

The only problem is exactly that, it will convert it to what it thinks it needs. If you have a lot of chronic stress, that DHEA will get converted to adrenaline - or if you do make testosterone and you have lots of fat, it will aromatize to a form of estrogen. Sometimes, you want it to do the opposite.

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